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Risk of subsequent prostate cancer in peptic ulcer patients who received helicobacter pylori eradication therapy: an Asian population-based cohort study
- Source :
- BMC Urology, Vol 20, Iss 1, Pp 1-7 (2020), BMC Urology
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Background Studies have shown diverse results regarding the association between H. pylori (HP) infection and the risk of malignancy. There is accumulating evidence relating HP infection to urological diseases. We investigated whether there was an association between HP-infected peptic ulcers and the subsequent risk of prostate cancer. Methods We collected HP-infected male patients from 1998 to 2008 from the Longitudinal Health Insurance Database (LHID). HP-infected patients were identified as those who had a diagnosis of peptic ulcers upon admission and received HP eradication therapy within 1 year after diagnosis. The date of HP infection diagnosis upon admission was defined as the index date. Patients aged Results A total of 2620 HP infection treatment patients and 10,480 matched comparisons were selected. There were 36 patients in the HP-infected treatment cohort and 117 patients in the comparison cohort with documented prostate cancer development (1.52 and 1.21 per 1000 person-years, respectively). Compared to the comparison cohort, the HP infection cohort had a 1.26-fold increased prostate cancer risk in the Cox models after adjusting for matched-pairs (95% CI = 0.87–1.34). There were no significant differences in subsequent prostate cancer development between HP-infected treatment patients and the comparison cohort. Conclusion Our findings showed no significant association between HP-infected peptic ulcers and the subsequent risk of prostate cancer. Further studies are warranted to investigate whether this observation is attributable to an HP eradication policy.
- Subjects :
- Adult
Male
medicine.medical_specialty
Urology
Peptic
030232 urology & nephrology
lcsh:RC870-923
Risk Assessment
Helicobacter Infections
Cohort Studies
Young Adult
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Asian People
Risk Factors
Internal medicine
medicine
Humans
Aged
Peptic ulcer
Helicobacter pylori
biology
Proportional hazards model
business.industry
Prostatic Neoplasms
Cancer
General Medicine
Middle Aged
lcsh:Diseases of the genitourinary system. Urology
biology.organism_classification
medicine.disease
Comorbidity
Prostatic cancer
Reproductive Medicine
030220 oncology & carcinogenesis
Cohort
Cohort study
business
H. pylori
Research Article
Subjects
Details
- ISSN :
- 14712490
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- BMC Urology
- Accession number :
- edsair.doi.dedup.....8599195d0f3bf08bc04d8c510f9a131a