Back to Search
Start Over
Bright Aggregation-Induced Emission Nanoparticles for Two-Photon Imaging and Localized Compound Therapy of Cancers
- Source :
- ACS nano. 14(12)
- Publication Year :
- 2020
-
Abstract
- Photodynamic therapy (PDT), a noninvasive therapeutic strategy for cancer treatment, which always suffers from the low reactive oxygen species (ROS) yield of traditional organic dyes. Herein, we present lipid-encapsulated aggregation-induced emission nanoparticles (AIE NPs) that have a high quantum yield (23%) and a maximum two-photon absorption (TPA) cross-section of 560 GM irradiated by near-infrared light (800 nm). The AIE NPs can serve as imaging agents for spatiotemporal imaging of tumor tissues with a penetration depth up to 505 μm on mice melanoma model. Importantly, the AIE NPs can simultaneously generate singlet oxygen (1O2) and highly toxic hydroxyl radicals (•OH) upon irradiation with 800 nm irradiation for photodynamic tumor ablation. In addition, the AIE NPs can be effectively cleared from the mouse body after the imaging and therapy. This study provides a strategy to develop theranostic agents for cancer image-guided PDT with high brightness, superior photostability, and high biosafety.
- Subjects :
- chemistry.chemical_classification
Reactive oxygen species
Singlet oxygen
medicine.medical_treatment
Radical
General Engineering
General Physics and Astronomy
Quantum yield
Nanoparticle
Photodynamic therapy
02 engineering and technology
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
0104 chemical sciences
chemistry.chemical_compound
chemistry
Two-photon excitation microscopy
Biophysics
medicine
General Materials Science
Irradiation
0210 nano-technology
Subjects
Details
- ISSN :
- 1936086X
- Volume :
- 14
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- ACS nano
- Accession number :
- edsair.doi.dedup.....8598cef6deae04b07863ce94bc401667