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Circulating interleukin-10 levels and human papilloma virus and Epstein–Barr virus-associated cancers: evidence from a Mendelian randomization meta-analysis based on 11,170 subjects
- Source :
- OncoTargets and therapy
- Publication Year :
- 2016
- Publisher :
- Dove Medical Press, 2016.
-
Abstract
- Kai Qu,1,* Qing Pang,1,* Ting Lin,1 Li Zhang,2 Mingliang Gu,3 Wenquan Niu,4 Chang Liu,1,* Ming Zhang5 1Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University College of Medicine, Xi’an, Shaanxi Province, People’s Republic of China; 2Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China; 3Chinese Academy of Sciences Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, People’s Republic of China; 4State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China; 5Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: Recent studies have showed interleukin 10 (IL-10) is a critical cytokine that determines antiviral immune response and is related to virus-associated cancers. However, whether genetically elevated circulating IL-10 levels are associated with the risk of human papilloma virus and Epstein–Barr virus-associated cancers (HEACs) is still unclear. Mendelian randomization method was implemented to meta-analyze available observational studies by employing IL-10 three variants (-592C>A, -819C>T, and -1082A>G) as instruments. Atotal of 24 articles encompassing 11,170 subjects were ultimately eligible for the meta-analysis. Overall, there was a significant association between IL-10 promoter variant -1082A>G and HEACs under allelic and dominant models (both PG was significant for nasopharyngeal cancer under allelic, homozygous genotypic and dominant models (all P
- Subjects :
- 0301 basic medicine
interleukin-10
medicine.disease_cause
Bioinformatics
OncoTargets and Therapy
03 medical and health sciences
0302 clinical medicine
human papilloma virus
Mendelian randomization
Genotype
Medicine
Epstein-Barr virus
Pharmacology (medical)
Allele
Original Research
business.industry
Mendelian Randomization Analysis
Odds ratio
Epstein–Barr virus
Confidence interval
meta-analysis
Interleukin 10
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Immunology
business
Subjects
Details
- Language :
- English
- ISSN :
- 11786930
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- OncoTargets and therapy
- Accession number :
- edsair.doi.dedup.....8597d16c8b9406d4a3f10be9129a8f4d