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Bioactive DNA-Peptide Nanotubes Enhance the Differentiation of Neural Stem Cells Into Neurons
- Source :
- Nano Letters
- Publication Year :
- 2014
- Publisher :
- American Chemical Society (ACS), 2014.
-
Abstract
- We report the construction of DNA nanotubes covalently functionalized with the cell adhesion peptide RGDS as a bioactive substrate for neural stem cell differentiation. Alteration of the Watson–Crick base pairing program that builds the nanostructures allowed us to probe independently the effect of nanotube architecture and peptide bioactivity on stem cell differentiation. We found that both factors instruct synergistically the preferential differentiation of the cells into neurons rather than astrocytes.
- Subjects :
- Nanotubes, Peptide
Letter
Materials science
Base pair
extracellular matrix
Cellular differentiation
Bioengineering
Peptide
Extracellular matrix
Mice
chemistry.chemical_compound
Neural Stem Cells
DNA nanotechnology
Animals
General Materials Science
Cell adhesion
Cells, Cultured
Neurons
chemistry.chemical_classification
Mechanical Engineering
Cell Differentiation
DNA
Self-assembly
General Chemistry
Condensed Matter Physics
DNA-peptide
Molecular biology
Neural stem cell
Cell biology
chemistry
Oligopeptides
biomaterials
Subjects
Details
- ISSN :
- 15306992 and 15306984
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Nano Letters
- Accession number :
- edsair.doi.dedup.....85899c84bca8fb54dd011511de9c92ba