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N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo
- Source :
- Translational Psychiatry, Translational Psychiatry, Vol 10, Iss 1, Pp 1-14 (2020), Translational Psychiatry, 10(1):331. Nature Publishing Group
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group UK, 2020.
-
Abstract
- N,N-dimethyltryptamine (DMT) is a component of the ayahuasca brew traditionally used for ritual and therapeutic purposes across several South American countries. Here, we have examined, in vitro and vivo, the potential neurogenic effect of DMT. Our results demonstrate that DMT administration activates the main adult neurogenic niche, the subgranular zone of the dentate gyrus of the hippocampus, promoting newly generated neurons in the granular zone. Moreover, these mice performed better, compared to control non-treated animals, in memory tests, which suggest a functional relevance for the DMT-induced new production of neurons in the hippocampus. Interestingly, the neurogenic effect of DMT appears to involve signaling via sigma-1 receptor (S1R) activation since S1R antagonist blocked the neurogenic effect. Taken together, our results demonstrate that DMT treatment activates the subgranular neurogenic niche regulating the proliferation of neural stem cells, the migration of neuroblasts, and promoting the generation of new neurons in the hippocampus, therefore enhancing adult neurogenesis and improving spatial learning and memory tasks.
- Subjects :
- 0301 basic medicine
Hallucinogen
Neurogenesis
Hippocampus
Biology
NEURAL STEM-CELLS
ASTROCYTES
Article
Subgranular zone
HIPPOCAMPAL NEUROGENESIS
lcsh:RC321-571
03 medical and health sciences
Cellular and Molecular Neuroscience
Mice
0302 clinical medicine
Neuroblast
Neural Stem Cells
N,N-Dimethyltryptamine
medicine
Animals
RECURRENT DEPRESSION
NEURONS
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Biological Psychiatry
SIGMA-1 RECEPTOR
Tea
Drug discovery
Dentate gyrus
MEMORY
Banisteriopsis
PROLIFERATION
Neural stem cell
Psychiatry and Mental health
030104 developmental biology
medicine.anatomical_structure
DIFFERENTIATION
DENTATE GYRUS
nervous system
Neuroscience
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 21583188
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Translational Psychiatry
- Accession number :
- edsair.doi.dedup.....8583479069c3311783decebb0588ce53