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XPD structure reveals its secrets
- Source :
- DNA Repair. 7:1912-1915
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- The XPD protein is central to our understanding of the relationship between NER deficiencies and human disorders. Three recent papers report the crystal structures of XPD from archaea. Apart from anticipated helicase domains the structures reveal a 4FeS cluster and novel "Arch" domain. The structures help our understanding of genotype-phenotype relationships in the XPD gene.
- Subjects :
- Models, Molecular
Genetics
Binding Sites
Sulfolobus acidocaldarius
Genotype
Models, Genetic
biology
Protein Conformation
Molecular Conformation
Helicase
Cell Biology
Crystallography, X-Ray
Models, Biological
Biochemistry
Molecular conformation
Protein Structure, Tertiary
Phenotype
Evolutionary biology
Mutation
Transcription factor II H
biology.protein
Humans
Molecular Biology
Protein Binding
Xeroderma Pigmentosum Group D Protein
Subjects
Details
- ISSN :
- 15687864
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- DNA Repair
- Accession number :
- edsair.doi.dedup.....857baa2cd47896085e0824974db66ba2
- Full Text :
- https://doi.org/10.1016/j.dnarep.2008.07.008