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Age and Multimorbidity Predict Death Among COVID-19 Patients: Results of the SARS-RAS Study of the Italian Society of Hypertension
- Publication Year :
- 2020
-
Abstract
- Several factors have been proposed to explain the high death rate of the coronavirus disease 2019 (COVID-19) outbreak, including hypertension and hypertension-related treatment with Renin Angiotensin System inhibitors. Also, age and multimorbidity might be confounders. No sufficient data are available to demonstrate their independent role. We designed a cross-sectional, observational, multicenter, nationwide survey in Italy to verify whether renin-angiotensin system inhibitors are related to COVID-19 severe outcomes. We analyzed information from Italian patients diagnosed with COVID-19, admitted in 26 hospitals. One thousand five hundred ninety-one charts (male, 64.1%; 66±0.4 years) were recorded. At least 1 preexisting condition was observed in 73.4% of patients, with hypertension being the most represented (54.9%). One hundred eighty-eight deaths were recorded (11.8%; mean age, 79.6±0.9 years). In nonsurvivors, older age, hypertension, diabetes mellitus, chronic obstructive pulmonary disease, chronic kidney disease, coronary artery diseases, and heart failure were more represented than in survivors. The Charlson Comorbidity Index was significantly higher in nonsurvivors compared with survivors (4.3±0.15 versus 2.6±0.05; P P =0.0001), diabetes mellitus ( P =0.004), chronic obstructive pulmonary disease ( P =0.011), and chronic kidney disease ( P =0.004) but not hypertension predicted mortality. Charlson Comorbidity Index, which cumulates age and comorbidities, predicts mortality with an exponential increase in the odds ratio by each point of score. In the COVID-19 outbreak, mortality is predicted by age and the presence of comorbidities. Our data do not support a significant interference of hypertension and antihypertensive therapy on COVID-19 lethality. Registration— URL: https://www.clinicaltrials.gov ; Unique identifier: NCT04331574.
- Subjects :
- Male
Cross-sectional study
Angiotensin-Converting Enzyme Inhibitors
030204 cardiovascular system & hematology
Renin-Angiotensin System
0302 clinical medicine
80 and over
Medicine
odds ratio
030212 general & internal medicine
Viral
Young adult
Societies, Medical
Aged, 80 and over
COVID-19
hypertension
Italy
multimorbidity
Adolescent
Adult
Age Distribution
Age Factors
Aged
Angiotensin Receptor Antagonists
Coronavirus Infections
Cross-Sectional Studies
Female
Humans
Hypertension
Middle Aged
Multimorbidity
Pandemics
Pneumonia, Viral
Prognosis
Survival Rate
Young Adult
Betacoronavirus
Mortality rate
medicine.medical_specialty
03 medical and health sciences
Internal medicine
Diabetes mellitus
Medical
Internal Medicine
Survival rate
business.industry
SARS-CoV-2
Odds ratio
Pneumonia
medicine.disease
Heart failure
business
Societies
Kidney disease
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....856e41899d6272d866557fcf67f28228