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Developmental trajectories of amygdala and hippocampus from infancy to early adulthood in healthy individuals
- Source :
- PLoS ONE, Vol 7, Iss 10, p e46970 (2012), PLoS ONE
- Publication Year :
- 2012
- Publisher :
- Public Library of Science (PLoS), 2012.
-
Abstract
- Knowledge of amygdalar and hippocampal development as they pertain to sex differences and laterality would help to understand not only brain development but also the relationship between brain volume and brain functions. However, few studies investigated development of these two regions, especially during infancy. The purpose of this study was to examine typical volumetric trajectories of amygdala and hippocampus from infancy to early adulthood by predicting sexual dimorphism and laterality. We performed a cross-sectional morphometric MRI study of amygdalar and hippocampal growth from 1 month to 25 years old, using 109 healthy individuals. The findings indicated significant non-linear age-related volume changes, especially during the first few years of life, in both the amygdala and hippocampus regardless of sex. The peak ages of amygdalar and hippocampal volumes came at the timing of preadolescence (9-11 years old). The female amygdala reached its peak age about one year and a half earlier than the male amygdala did. In addition, its rate of growth change decreased earlier in the females. Furthermore, both females and males displayed rightward laterality in the hippocampus, but only the males in the amygdala. The robust growth of the amygdala and hippocampus during infancy highlight the importance of this period for neural and functional development. The sex differences and laterality during development of these two regions suggest that sex-related factors such as sex hormones and functional laterality might affect brain development.
- Subjects :
- Male
Aging
Anatomy and Physiology
Physiology
Hippocampus
lcsh:Medicine
Developmental and Pediatric Neurology
Hippocampal formation
Pediatrics
Functional Laterality
Pregnancy
Psychology
Young adult
Child
lcsh:Science
Sex Characteristics
Multidisciplinary
Organ Size
Amygdala
Mental Health
medicine.anatomical_structure
Neurology
Health
Child, Preschool
Brain size
Laterality
Medicine
Female
Research Article
Sex characteristics
Adult
medicine.medical_specialty
Adolescent
Neurophysiology
Neuroimaging
Biology
Neurological System
Young Adult
Developmental Neuroscience
medicine
Humans
Psychiatry
lcsh:R
Infant, Newborn
Infant
Sexual dimorphism
Neuroanatomy
nervous system
Developmental Psychology
lcsh:Q
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 7
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....856cd61a104734a3b2daa69cef5b14f8