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Urinary 8-Hydroxy-2′-deoxyguanosine (8-OHdG) Concentrations and Menstrual Cycle Characteristics in Female University Students
- Source :
- International Journal of Environmental Research and Public Health, Volume 15, Issue 12, International Journal of Environmental Research and Public Health, Vol 15, Iss 12, p 2616 (2018)
- Publication Year :
- 2018
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2018.
-
Abstract
- Higher concentrations of oxidative stress biomarkers are found in women with polycystic ovary syndrome (PCOS) and endometriosis, conditions linked to irregular menstrual cycles and menstrual pain. The aim of the present study was to test whether women with higher oxidative stress are more likely to show irregular menstrual cycles and severe menstrual pain compared with women with lower oxidative stress. A cross-sectional study was conducted targeting female university students with a mean (SD) age of 20.5 (1.8) years (n = 188). Participants completed a questionnaire on reproductive characteristics and anthropometry and kept a menstrual cycle diary for 5 consecutive months. Urinary 8-hydroxy-2&prime<br />deoxyguanosine (8-OHdG), cotinine, and creatinine concentrations were measured once during the study period. The mean (SD) value of the urinary 8-OHdG concentration was 4.7 (2.0) &mu<br />g/g of creatinine. A total of 1021 menstrual cycles were recorded. The participants were categorized as either having regular (68%) or irregular (18%) cycles or oligomenorrhea (13%) or polymenorrhea (1%). The urinary 8-OHdG concentration did not significantly differ across menstrual cycle regularity or pain categories. Even after adjusting for age, body mass index (BMI), and urinary cotinine concentrations, having irregular cycles or more severe menstrual pain was not associated with urinary 8-OHdG concentration.
- Subjects :
- Adult
Universities
Health, Toxicology and Mutagenesis
media_common.quotation_subject
Urinary system
Endometriosis
Physiology
lcsh:Medicine
Article
03 medical and health sciences
chemistry.chemical_compound
Young Adult
0302 clinical medicine
Dysmenorrhea
menstrual pain
Medicine
Humans
oxidative stress
030212 general & internal medicine
Polymenorrhea
Students
Menstrual cycle
Menstrual Cycle
Menstruation Disturbances
media_common
Creatinine
young women
030219 obstetrics & reproductive medicine
business.industry
lcsh:R
Public Health, Environmental and Occupational Health
Deoxyguanosine
medicine.disease
Polycystic ovary
Cross-Sectional Studies
chemistry
8-Hydroxy-2'-Deoxyguanosine
menstrual cycle regularity
Female
Cotinine
business
Body mass index
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 16604601
- Database :
- OpenAIRE
- Journal :
- International Journal of Environmental Research and Public Health
- Accession number :
- edsair.doi.dedup.....856a85f7119f7c7c929fda730f2b030a
- Full Text :
- https://doi.org/10.3390/ijerph15122616