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Urinary 8-Hydroxy-2′-deoxyguanosine (8-OHdG) Concentrations and Menstrual Cycle Characteristics in Female University Students

Authors :
Jun Yoshinaga
Youichi Chisaki
Hideki Imai
Yu Onoda
Yukiko Nishihama
Shoko Konishi
Source :
International Journal of Environmental Research and Public Health, Volume 15, Issue 12, International Journal of Environmental Research and Public Health, Vol 15, Iss 12, p 2616 (2018)
Publication Year :
2018
Publisher :
Multidisciplinary Digital Publishing Institute, 2018.

Abstract

Higher concentrations of oxidative stress biomarkers are found in women with polycystic ovary syndrome (PCOS) and endometriosis, conditions linked to irregular menstrual cycles and menstrual pain. The aim of the present study was to test whether women with higher oxidative stress are more likely to show irregular menstrual cycles and severe menstrual pain compared with women with lower oxidative stress. A cross-sectional study was conducted targeting female university students with a mean (SD) age of 20.5 (1.8) years (n = 188). Participants completed a questionnaire on reproductive characteristics and anthropometry and kept a menstrual cycle diary for 5 consecutive months. Urinary 8-hydroxy-2&prime<br />deoxyguanosine (8-OHdG), cotinine, and creatinine concentrations were measured once during the study period. The mean (SD) value of the urinary 8-OHdG concentration was 4.7 (2.0) &mu<br />g/g of creatinine. A total of 1021 menstrual cycles were recorded. The participants were categorized as either having regular (68%) or irregular (18%) cycles or oligomenorrhea (13%) or polymenorrhea (1%). The urinary 8-OHdG concentration did not significantly differ across menstrual cycle regularity or pain categories. Even after adjusting for age, body mass index (BMI), and urinary cotinine concentrations, having irregular cycles or more severe menstrual pain was not associated with urinary 8-OHdG concentration.

Details

Language :
English
ISSN :
16604601
Database :
OpenAIRE
Journal :
International Journal of Environmental Research and Public Health
Accession number :
edsair.doi.dedup.....856a85f7119f7c7c929fda730f2b030a
Full Text :
https://doi.org/10.3390/ijerph15122616