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Fish oil supplementation attenuates changes in plasma lipids caused by dexamethasone treatment in rats
- Source :
- Applied Physiology, Nutrition, and Metabolism. 41:382-390
- Publication Year :
- 2016
- Publisher :
- Canadian Science Publishing, 2016.
-
Abstract
- Dexamethasone is an anti-inflammatory glucocorticoid that may alter glucose and lipid homeostasis when administered in high doses or for long periods of time. Omega-3 fatty acids, present in fish oil (FO), can be used as potential modulators of intermediary glucose and lipid metabolism. Herein, we evaluate the effects of FO supplementation (1 g·kg–1body weight (BW)) on glucose and lipid metabolism in rats treated with dexamethasone (0.5 mg·kg–1BW) for 15 days. Adult male Wistar rats were distributed among 4 groups: control (saline, 1 mL·kg–1BW and mineral oil, 1 g·kg–1BW), DEX (dexamethasone and mineral oil), FO (fish oil and saline), and DFO (fish oil and dexamethasone). Dexamethasone and saline were administered intraperitoneally, and fish oil and mineral oil were administered by gavage. We evaluated functional and molecular parameters of lipid and glycemic profiles at 8 days and at the end of treatment. FO supplementation increased hepatic docosahexaenoic acid (DEX: 5.6% ± 0.7%; DFO: 10.5% ± 0.8%) and eicosapentaenoic acid (DEX: 0.3% ± 0.0%; DFO: 1.3% ± 0.1%) contents and attenuated the increase of plasma triacylglycerol, total cholesterol, and non–high-density lipoprotein cholesterol concentrations in DFO rats compared with DEX rats. These effects seem not to depend on hepatic expression of insulin receptor substrate 1, protein kinase B, peroxisome proliferator-activated receptor γ coactivator 1-α, and peroxisome proliferator-activated receptor γ. There was no effect of supplementation on body weight loss, fasting glycemia, and glucose tolerance in rats treated with dexamethasone. In conclusion, we show that FO supplementation for 15 days attenuates the dyslipidemia induced by dexamethasone treatment.
- Subjects :
- Blood Glucose
Male
0301 basic medicine
medicine.medical_specialty
Docosahexaenoic Acids
Physiology
Endocrinology, Diabetes and Metabolism
Blood sugar
Blood lipids
Dexamethasone
03 medical and health sciences
Fish Oils
Physiology (medical)
Internal medicine
Fatty Acids, Omega-3
medicine
Animals
Rats, Wistar
Triglycerides
Dyslipidemias
Nutrition and Dietetics
Chemistry
Body Weight
Cholesterol, HDL
Lipid metabolism
Cholesterol, LDL
General Medicine
Lipid Metabolism
Fish oil
Eicosapentaenoic acid
Rats
PPAR gamma
030104 developmental biology
Endocrinology
Eicosapentaenoic Acid
Liver
Docosahexaenoic acid
Dietary Supplements
Insulin Receptor Substrate Proteins
Proto-Oncogene Proteins c-akt
Glucocorticoid
medicine.drug
Subjects
Details
- ISSN :
- 17155320 and 17155312
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Applied Physiology, Nutrition, and Metabolism
- Accession number :
- edsair.doi.dedup.....8562ce22d3113cc27ad93e4e28ee70bd
- Full Text :
- https://doi.org/10.1139/apnm-2015-0487