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An Update on Neurofibromatosis Type 1-Associated Gliomas
- Source :
- Cancers, Cancers, Vol 12, Iss 1, p 114 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition syndrome that affects children and adults. Individuals with NF1 are at high risk for central nervous system neoplasms including gliomas. The purpose of this review is to discuss the spectrum of intracranial gliomas arising in individuals with NF1 with a focus on recent preclinical and clinical data. In this review, possible mechanisms of gliomagenesis are discussed, including the contribution of different signaling pathways and tumor microenvironment. Furthermore, we discuss the recent notable advances in the developing therapeutic landscape for NF1-associated gliomas including clinical trials and collaborative efforts.
- Subjects :
- Oncology
congenital, hereditary, and neonatal diseases and abnormalities
Cancer Research
medicine.medical_specialty
Review
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Internal medicine
Tumor predisposition syndrome
therapeutics
medicine
Neurofibromatosis
astrocytoma
neoplasms
Tumor microenvironment
neurofibromatosis
business.industry
glioblastoma
Astrocytoma
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
nervous system diseases
gliomas
Clinical trial
030220 oncology & carcinogenesis
business
030217 neurology & neurosurgery
Glioblastoma
Subjects
Details
- ISSN :
- 20726694
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Cancers
- Accession number :
- edsair.doi.dedup.....85535a0f1101f1279766260f94a3fd7f