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Establishment and Application of Prostate Cancer Circulating Tumor Cells in the Era of Precision Medicine
- Source :
- BioMed Research International, BioMed Research International, Vol 2017 (2017)
- Publication Year :
- 2017
- Publisher :
- Hindawi Limited, 2017.
-
Abstract
- Prostate cancer (PC) is the second most common cancer in men and is the fifth leading cause of cancer-related deaths worldwide. Additionally, there is concern for overdiagnosis and overtreatment of PC. Thus, selection of an appropriate candidate for active surveillance as well as more accurate and less invasive tools for monitoring advanced PC is required. Circulating tumor cells (CTCs) have emerged as a liquid biopsy tool; there have been several reports on its role, technologies, and applications to various cancers, including PC. Liquid biopsy using CTCs has been gaining attention as a minimal invasive tool for investigation of biomarkers and for prognosis and assessment of response to therapies in patients with PC. Because of the lower invasiveness of liquid biopsy using CTCs, it can be performed more frequently; accordingly, personalized disease status can be successively determined at serial time points. CTC analysis enables detection of genomic alterations, which is drug-targetable, and it is a potential tool for monitoring response to therapeutic agents in patients with PC. This review focuses on the characteristics, technologies for analysis, and advantages and disadvantages of CTCs as a liquid biopsy tool and their application in PC. Finally, we propose future directions of CTCs.
- Subjects :
- Male
0301 basic medicine
Oncology
medicine.medical_specialty
Disease status
Pathology
Biopsy
lcsh:Medicine
Review Article
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Circulating tumor cell
Internal medicine
Biomarkers, Tumor
medicine
Humans
In patient
Precision Medicine
Overdiagnosis
Liquid biopsy
General Immunology and Microbiology
business.industry
lcsh:R
Prostatic Neoplasms
Cancer
General Medicine
Neoplastic Cells, Circulating
Precision medicine
medicine.disease
030104 developmental biology
030220 oncology & carcinogenesis
business
Subjects
Details
- ISSN :
- 23146141 and 23146133
- Volume :
- 2017
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....854e6329e6c0fd4bb591792caf861a47