The Changing Burden of Pediatric Bloodstream Infections in Calgary, Canada, 2000–2006

Background: The epidemiology of pediatric bloodstream infection has not been well defined in general populations. The primary objective of this study was to describe the burden of illness of pediatric bloodstream infections in a large Canadian region and secondarily to assess the effect of implementation of universal infant immunization with 7-valent pneumococcal conjugate vaccine (PCV7) in 2002. Methods: Surveillance for all bloodstream infections was conducted among pediatric (