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Differences in brain volumes among males and female hormone-therapy users and nonusers

Differences in brain volumes among males and female hormone-therapy users and nonusers

Authors :
Daniel L. Greenberg
James M. Provenzale
James R. MacFall
David C. Steffens
Ranga Krishnan
Martha E. Payne
Source :
Psychiatry research. 147(2-3)
Publication Year :
2005

Abstract

Numerous studies have shown gender differences in the brain volumes of elderly adults. Some evidence shows that higher estrogen levels may be neuroprotective, suggesting that hormone therapy (HT) may in part be responsible for these gender differences; however, few studies have examined the relation between HT and brain volumes. Brain volumes of caudate, putamen, hippocampus, gray matter, white matter, white-matter lesions, and cerebrospinal fluid were measured on magnetic resonance imaging scans. A comprehensive neuropsychological battery was administered. Women were separated into two groups based on HT use, and we used multiple regression analyses to compare these groups with one another and with men. Results of brain-volume measurements showed that HT users had significantly less gray matter and more cerebrospinal fluid than nonusers. Results of the neuropsychological testing showed that HT users performed better on the Shipley Vocabulary Test than males did.

Details

ISSN :
01651781
Volume :
147
Issue :
2-3
Database :
OpenAIRE
Journal :
Psychiatry research
Accession number :
edsair.doi.dedup.....854950e2f8142bd50355825ae0a590cf