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The multifarious regulation of the apical junctional complex
- Source :
- Open Biology, Open Biology, Vol 10, Iss 2 (2020)
- Publication Year :
- 2020
- Publisher :
- The Royal Society, 2020.
-
Abstract
- Epithelial cells form highly organized polarized sheets with characteristic cell morphologies and tissue architecture. Cell–cell adhesion and intercellular communication are prerequisites of such cohesive sheets of cells, and cell connectivity is mediated through several junctional assemblies, namely desmosomes, adherens, tight and gap junctions. These cell–cell junctions form signalling hubs that not only mediate cell–cell adhesion but impact on multiple aspects of cell behaviour, helping to coordinate epithelial cell shape, polarity and function. This review will focus on the tight and adherens junctions, constituents of the apical junctional complex, and aims to provide a comprehensive overview of the complex signalling that underlies junction assembly, integrity and plasticity.
- Subjects :
- Immunology
Cell
Review
Review Article
Cell Communication
Biology
cytoskeletal regulators
Cell junction
General Biochemistry, Genetics and Molecular Biology
Adherens junction
03 medical and health sciences
0302 clinical medicine
Rho GTPases
Cell Adhesion
medicine
Animals
Humans
Gene Regulatory Networks
lcsh:QH301-705.5
030304 developmental biology
0303 health sciences
Polarity (international relations)
General Neuroscience
Gap junction
Cell Polarity
Gap Junctions
junction integrity
Epithelial Cells
Adherens Junctions
Desmosomes
Adhesion
Epithelium
Cell biology
junction recycling
Intercellular Junctions
medicine.anatomical_structure
lcsh:Biology (General)
junction assembly
cell–cell adhesion
030217 neurology & neurosurgery
Intracellular
Subjects
Details
- ISSN :
- 20462441
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Open Biology
- Accession number :
- edsair.doi.dedup.....85449a97a2c0d43a9e9836ed9dd45887