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NADPH oxidase activation in neutrophils: Role of the phosphorylation of its subunits
- Source :
- European Journal of Clinical Investigation, European Journal of Clinical Investigation, Wiley, 2018, 48, pp.e12951. ⟨10.1111/eci.12951⟩
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- Neutrophils are key cells of innate immunity and during inflammation. Upon activation, they produce large amounts of superoxide anion (O2 -. ) and ensuing reactive oxygen species (ROS) to kill phagocytized microbes. The enzyme responsible for O2 -. production is called the phagocyte NADPH oxidase. This is a multicomponent enzyme system that becomes active after assembly of four cytosolic proteins (p47phox , p67phox , p40phox and Rac2) with the transmembrane proteins (p22phox and gp91phox , which form the cytochrome b558 ). gp91phox represents the catalytic subunit of the NADPH oxidase and is also called NOX2. NADPH oxidase-derived ROS are essential for microbial killing and innate immunity; however, excessive ROS production induces tissue injury and prolonged inflammatory reactions that contribute to inflammatory diseases. Thus, NADPH oxidase activation must be tightly regulated in time and space to limit ROS production. NADPH oxidase activation is regulated by several processes such as phosphorylation of its components, exchange of GDP/GTP on Rac2 and binding of p47phox and p40phox to phospholipids. This review aims to provide new insights into the role of the phosphorylation of the NADPH oxidase components, that is gp91phox , p22phox , p47phox , p67phox and p40phox , in the activation of this enzyme.
- Subjects :
- 0301 basic medicine
Neutrophils
Clinical Biochemistry
Enzyme Activators
Biochemistry
[SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Bacterial Proteins
Humans
Protein phosphorylation
Phosphorylation
ComputingMilieux_MISCELLANEOUS
chemistry.chemical_classification
Reactive oxygen species
NADPH oxidase
Innate immune system
biology
Superoxide
NADPH Oxidases
General Medicine
Phosphoproteins
Cell biology
Enzyme Activation
030104 developmental biology
Enzyme
chemistry
030220 oncology & carcinogenesis
NADPH Oxidase 2
biology.protein
Tetradecanoylphorbol Acetate
P22phox
Subjects
Details
- Language :
- English
- ISSN :
- 00142972 and 13652362
- Database :
- OpenAIRE
- Journal :
- European Journal of Clinical Investigation, European Journal of Clinical Investigation, Wiley, 2018, 48, pp.e12951. ⟨10.1111/eci.12951⟩
- Accession number :
- edsair.doi.dedup.....85349414d3bc930d0547829a404cf2d1