Novel Varicella-Zoster Virus Glycoprotein E Gene Mutations Associated with Genotypes A and D

Here, we describe the association of certain varicella-zoster virus (VZV) genotypes with unique glycoprotein E (gE) gene mutations. Within 45 analyzed VZV wild-type strains of genotypes A and D, five novel gE mutations were discovered. A statistically significant ( P < 0.0001) association of certain gE mutations with VZV genotype D was found.