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Risk of heart failure in type 2 diabetes complicated by incident ischaemic heart disease and end-stage renal disease
- Source :
- Malik, M E, Madelaire, C, D'Souza, M, Blanche, P, Kristensen, S L, Kistorp, C, Gustafsson, F, Køber, L, Rørth, R, McMurray, J, Sattar, N, Gislason, G, Torp-Pedersen, C & Schou, M 2020, ' Risk of heart failure in type 2 diabetes complicated by incident ischaemic heart disease and end-stage renal disease ', European Journal of Heart Failure, vol. 22, no. 5, pp. 813-820 . https://doi.org/10.1002/ejhf.1819
- Publication Year :
- 2019
-
Abstract
- AIMS: To evaluate the risk of heart failure (HF) in patients with type 2 diabetes (T2D) complicated by development of intercurrent ischaemic heart disease (IHD), end-stage renal disease (ESRD), or both, compared to patients with T2D and no IHD and ESRD.METHODS AND RESULTS: From Danish nationwide registries, we identified all patients with new-onset T2D with no history of HF between 1998 and 2015. Landmark analyses were used to estimate the 5-year absolute risk of HF at several follow-up times, and accounted for the occurrence of IHD and ESRD, identified before HF. The Aalen-Johansen estimator was used to account for censoring and the competing risk of death. A total of 285 024 patients with new-onset T2D were included. During follow-up, 19 960 developed incident HF. Among patients with T2D free of HF 5 years after T2D diagnosis, patients without IHD and ESRD had the lowest 5-year risk of HF [4.02%; 95% confidence interval (CI) 3.90-4.15), those with T2D complicated by IHD [11.51%; relative risk (RR) 2.86; 95% CI 2.72-3.02; P CONCLUSION: Patients with T2D complicated by development of intercurrent IHD, ESRD, or both, showed a significantly higher risk of HF compared to those who did not develop IHD and ESRD. An effective way to delay or prevent the development of HF in patients with T2D may be to prevent IHD and ESRD.
- Subjects :
- medicine.medical_specialty
endocrine system diseases
Epidemiology
Myocardial Ischemia
Heart failure
Type 2 diabetes
Disease
030204 cardiovascular system & hematology
urologic and male genital diseases
End stage renal disease
End-stage renal disease
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
cardiovascular diseases
Heart Failure
business.industry
Absolute risk reduction
medicine.disease
Confidence interval
Diabetes Mellitus, Type 2
Relative risk
Cardiology
Kidney Failure, Chronic
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 18790844
- Volume :
- 22
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- European journal of heart failureReferences
- Accession number :
- edsair.doi.dedup.....852535ca2f060979095888c19ba5e1ef