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Bioactive silicon nitride: A new therapeutic material for osteoarthropathy
- Source :
- Scientific Reports
- Publication Year :
- 2017
- Publisher :
- Nature Publishing Group, 2017.
-
Abstract
- While the reciprocity between bioceramics and living cells is complex, it is principally governed by the implant’s surface chemistry. Consequently, a deeper understanding of the chemical interactions of bioceramics with living tissue could ultimately lead to new therapeutic strategies. However, the physical and chemical principles that govern these interactions remain unclear. The intricacies of this biological synergy are explored within this paper by examining the peculiar surface chemistry of a relatively new bioceramic, silicon nitride (Si3N4). Building upon prior research, this paper aims at obtaining new insights into the biological interactions between Si3N4 and living cells, as a consequence of the off-stoichiometric chemical nature of its surface at the nanometer scale. We show here yet unveiled details of surface chemistry and, based on these new data, formulate a model on how, ultimately, Si3N4 influences cellular signal transduction functions and differentiation mechanisms. In other words, we interpret its reciprocity with living cells in chemical terms. These new findings suggest that Si3N4 might provide unique new medicinal therapies and effective remedies for various bone or joint maladies and diseases.
- Subjects :
- Cell Survival
Surface Properties
Computer science
Animals
Cell Line
Cells, Cultured
Humans
Materials Testing
Microscopy, Confocal
Models, Biological
Osteoarthritis
Spectroscopy, Fourier Transform Infrared
Spectrum Analysis, Raman
Biocompatible Materials
Silicon Compounds
Cells
Nanotechnology
02 engineering and technology
Bioceramic
Materials testing
Chemical interaction
010402 general chemistry
01 natural sciences
Article
Models
Raman
Spectroscopy
Cell survival
Microscopy
Cultured
Multidisciplinary
Spectrum Analysis
Scale (chemistry)
Biological
021001 nanoscience & nanotechnology
Biocompatible material
Cellular signal transduction
Reciprocity (evolution)
0104 chemical sciences
Fourier Transform Infrared
Confocal
0210 nano-technology
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....8522f037548985d1f2db450e32e2732d
- Full Text :
- https://doi.org/10.1038/srep44848