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Current and emerging medications for borderline personality disorder: is pharmacotherapy alone enough?
- Source :
- Expert opinion on pharmacotherapy. 21(1)
- Publication Year :
- 2019
-
Abstract
- Introduction: The treatment of borderline personality disorder (BPD) remains an open question for clinicians. There is scarce evidence available and the guidelines' conclusions diverge. Together with these factors, the complexity of BPD generates uncertainty in day-to-day practice. This narrative review aims to provide an overview of advances in BPD treatment and posit a critical opinion based on clinical evidence and practice.Areas covered: The authors review the clinical trials concerning the efficacy of the main classes of drugs in BPD: antidepressants, mood stabilizers, first-, second-, and third-generation antipsychotics, and other agents (opiate antagonists, clonidine, oxytocin, omega-3 fatty acids). They also include in this review studies on combinations of drugs and psychotherapies.Expert opinion: An individualized, tailored pharmacotherapy for BPD that targets the prominent symptom clusters can improve relevant aspects of the clinical picture. However, no medication is indicated to treat the global psychopathology of BPD. Polypharmacy should be avoided or strictly limited. To date, pharmacotherapy alone does not suffice to manage the complexity of BPD. Combining medication with psychotherapy may improve specific BPD symptom dimensions. In particular, it may help those aspects that respond slowly or not at all to monotherapy.
- Subjects :
- Psychotherapist
Borderline personality disorder, pharmacotherapy, psychotherapy, combined therapy, antidepressants, mood stabilizers, antipsychotics
behavioral disciplines and activities
03 medical and health sciences
pharmacotherapy
0302 clinical medicine
Pharmacotherapy
combined therapy
Antimanic Agents
Borderline Personality Disorder
mental disorders
Fatty Acids, Omega-3
medicine
Humans
Pharmacology (medical)
Borderline personality disorder
Pharmacology
Polypharmacy
business.industry
General Medicine
medicine.disease
Antidepressive Agents
Clonidine
Clinical trial
Psychotherapy
mood stabilizers
antipsychotics
Mood
030220 oncology & carcinogenesis
antidepressants
Narrative review
Anticonvulsants
business
030217 neurology & neurosurgery
Psychopathology
medicine.drug
Antipsychotic Agents
Subjects
Details
- ISSN :
- 17447666
- Volume :
- 21
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Expert opinion on pharmacotherapy
- Accession number :
- edsair.doi.dedup.....8513b78ff11613ec7462173b77aebd22