Back to Search
Start Over
Defining the effects of age and gender on immune response and outcomes to melanoma vaccination: a retrospective analysis of a single-institution clinical trials’ experience
- Source :
- Cancer Immunology, Immunotherapy. 64:1531-1539
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- The impacts of patient age and gender on immune response (IR) and clinical outcome after cancer vaccines are not known. We hypothesized younger and female patients would have higher IR rates and better survival.Patients with resected stage IIB-IV melanoma in three clinical trials (Mel43, Mel44, Mel48) were vaccinated with 12 melanoma-associated peptides restricted by class I MHC. The cumulative incidence rate of CD8(+) T cell responses (direct interferon-gamma ELIspot assay) by week 7 was compared by age and gender. Overall survival (OS) and disease-free survival (DFS) landmark analyses were compared by Kaplan-Meier estimates and in multivariate analyses.T cell responses were evaluated in 327 patients and detected in 50 % of males and 48 % of females, with no difference in IR by gender or menopausal status. Males had trends toward longer DFS (p = 0.12) and OS (p = 0.09). Cumulative incidence of IR was higher in patients64 years of age versus older patients (p = 0.03). OS and DFS were similar by age group (p0.50). In multivariate modeling, younger age was associated with better IR (OR 0.40, p value 0.003), without an impact of age or gender on clinical outcomes.These data support the hypothesis that older patients are less likely to develop T cell responses to a cancer vaccine. Nonetheless, significant proportions of older patients mount immune responses with comparable survival outcomes. Thus, these data support including older patients in cancer vaccine trials, but suggest value in stratifying patients by age/64 years.
- Subjects :
- Adult
Male
Oncology
Cancer Research
medicine.medical_specialty
Multivariate analysis
Immunology
Adaptive Immunity
Cancer Vaccines
Article
Disease-Free Survival
Sex Factors
Internal medicine
medicine
Humans
Immunology and Allergy
Cumulative incidence
Melanoma
Aged
Retrospective Studies
Aged, 80 and over
business.industry
Age Factors
Cancer
Retrospective cohort study
Middle Aged
medicine.disease
Clinical trial
Vaccination
Treatment Outcome
Multivariate Analysis
Vaccines, Subunit
Female
Cancer vaccine
business
CD8
Subjects
Details
- ISSN :
- 14320851 and 03407004
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Cancer Immunology, Immunotherapy
- Accession number :
- edsair.doi.dedup.....8511f7b320fba368d0a9c105ddae3166