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Non-small cell lung cancer: whole-body MR examination for M-stage assessment--utility for whole-body diffusion-weighted imaging compared with integrated FDG PET/CT
- Source :
- Radiology. 248(2)
- Publication Year :
- 2008
-
Abstract
- To prospectively and directly compare the capability of whole-body diffusion-weighted (DW) imaging, whole-body magnetic resonance (MR) imaging with and that without DW imaging, and integrated fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) for M-stage assessment in non-small cell lung cancer (NSCLC) patients.The institutional review board approved this study; informed consent was obtained from patients. A total of 203 NSCLC patients (109 men, 94 women; mean age, 72 years) prospectively underwent whole-body DW imaging, whole-body MR imaging, and FDG PET/CT. Final diagnosis of the M-stage in each patient was determined on the basis of results of all radiologic and follow-up examinations. Two chest radiologists and two nuclear medicine physicians independently assessed all examination results and used a five-point visual scoring system to evaluate the probability of metastases. Final diagnosis based on each of the methods was made by consensus of two readers. Receiver operating characteristic (ROC) analysis was used to compare the capability for M-stage assessment among whole-body DW imaging, whole-body MR imaging with and that without DW imaging, and PET/CT on a per-patient basis. Sensitivity, specificity, and accuracy were compared with the McNemar test.Area under ROC curve (A(z)) values of whole-body MR imaging with DW imaging (A(z) = 0.87, P = .04) and integrated FDG PET/CT (A(z) = 0.89, P = .02) were significantly larger than that of whole-body DW imaging (A(z) = 0.79). Specificity and accuracy of whole-body MR imaging with (specificity, P = .02; accuracy, P.01) and that without DW imaging (specificity, P = .02; accuracy, P = .01) and integrated FDG PET/CT (specificity, P.01; accuracy, P.01) were significantly higher than those of whole-body DW imaging.Whole-body MR imaging with DW imaging can be used for M-stage assessment in NSCLC patients with accuracy as good as that of PET/CT.
- Subjects :
- Male
medicine.medical_specialty
Lung Neoplasms
Whole body imaging
Contrast Media
Gadolinium
Sensitivity and Specificity
Fluorodeoxyglucose F18
Heterocyclic Compounds
Carcinoma, Non-Small-Cell Lung
medicine
Image Processing, Computer-Assisted
Organometallic Compounds
Humans
Radiology, Nuclear Medicine and imaging
Whole Body Imaging
Prospective Studies
Stage (cooking)
Lung cancer
Aged
Neoplasm Staging
Aged, 80 and over
Analysis of Variance
medicine.diagnostic_test
business.industry
Cancer
Magnetic resonance imaging
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Diffusion Magnetic Resonance Imaging
ROC Curve
Positron emission tomography
Positron-Emission Tomography
Female
Radiology
Tomography
Radiopharmaceuticals
business
Nuclear medicine
Tomography, X-Ray Computed
Diffusion MRI
Subjects
Details
- ISSN :
- 15271315
- Volume :
- 248
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Radiology
- Accession number :
- edsair.doi.dedup.....851094db86fc81119b149ad5b3bef2e5