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A new primate model for multiple sclerosis in the common marmoset
- Source :
- Immunology Today, 21(6), 290-297. Elsevier Ltd.
- Publication Year :
- 2000
-
Abstract
- Experimental autoimmune encephalomyelitis (EAE) in outbred marmoset monkeys (Callithrix jacchus) is a recently developed nonhuman primate model of multiple sclerosis. Here, Bert 't Hart and colleagues compare this model to EAE in rhesus monkeys, highlighting autoimmune mechanisms in CNS inflammation and demyelination, including the role of major histocompatibility complex restriction and preclinical evaluation of innovative immunotherapies.
- Subjects :
- Encephalomyelitis, Autoimmune, Experimental
Multiple Sclerosis
animal diseases
Encephalomyelitis
medicine.medical_treatment
Immunology
Genes, MHC Class II
Receptors, Antigen, T-Cell
Twins
Rodentia
Major histocompatibility complex
Autoimmune Diseases
Species Specificity
biology.animal
Histocompatibility Antigens
medicine
Animals
Primate
CD40 Antigens
biology
Chimera
Multiple sclerosis
Experimental autoimmune encephalomyelitis
Marmoset
Antibodies, Monoclonal
Callithrix
Cercopithecidae
Immunotherapy
Interferon-beta
medicine.disease
biology.organism_classification
Rats
Disease Models, Animal
Desensitization, Immunologic
Rats, Inbred Lew
Cebidae
Acute Disease
biology.protein
Disease Susceptibility
Rolipram
Immunosuppressive Agents
Demyelinating Diseases
Subjects
Details
- ISSN :
- 01675699
- Volume :
- 21
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Immunology today
- Accession number :
- edsair.doi.dedup.....8506a32d9f1c20b34a847a19c94e96bf