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Effects of intra-accumbal administration of dopamine and ionotropic glutamate receptor drugs on delay discounting performance in rats
- Source :
- Behavioral Neuroscience. 131:392-405
- Publication Year :
- 2017
- Publisher :
- American Psychological Association (APA), 2017.
-
Abstract
- Nucleus accumbens core (NAcc) has been implicated in impulsive choice, as measured in delay discounting. The role of dopamine (DA) in impulsive choice has received considerable attention, whereas glutamate (Glu) has recently been shown to be an important mediator of discounting. However, research has not examined how DA or Glu receptors in NAcc mediate different aspects of delay discounting performance, that is, (a) sensitivity to reinforcer magnitude and (b) sensitivity to delayed reinforcement. Adult male Sprague-Dawley rats were first trained in a delay discounting task, in which the delay to a large magnitude food reinforcer increased across blocks of trials. Following behavioral training, rats received bilateral implantation of guide cannulas into NAcc. Half of the rats (n = 12) received infusions of the DA-selective ligands SKF 38393 (D1-like agonist: 0.03 or 0.1 μg), SCH 23390 (D1-like antagonist: 0.3 or 1.0 μg), quinpirole (D2-like agonist: 0.3 or 1.0 μg), and eticlopride (D2-like antagonist: 0.3 or 1.0 μg). The other half received infusions of the ionotropic Glu ligands MK-801 (NMDA uncompetitive antagonist: 0.3 or 1.0 μg), AP-5 (NMDA competitive antagonist: 0.3 or 1.0 μg), ifenprodil (noncompetitive antagonist at NR2B-containing NMDA receptors: 0.3 or 1.0 μg), and CNQX (AMPA competitive antagonist: 0.2 or 0.5 μg). Results showed that SCH 23390 (0.3 μg) decreased sensitivity to reinforcer magnitude without altering impulsive choice, whereas ifenprodil (1.0 μg) decreased sensitivity to delayed reinforcement (i.e., impulsive choice). The current results show that DA and NMDA receptors in NAcc mediate distinct aspects of discounting performance. (PsycINFO Database Record
- Subjects :
- Male
Agonist
Quinpirole
medicine.drug_class
Dopamine
Glutamic Acid
Pharmacology
Receptors, Ionotropic Glutamate
Choice Behavior
Receptors, N-Methyl-D-Aspartate
Nucleus Accumbens
Article
Rats, Sprague-Dawley
03 medical and health sciences
Behavioral Neuroscience
chemistry.chemical_compound
0302 clinical medicine
Uncompetitive antagonist
Eticlopride
Salicylamides
Ifenprodil
medicine
Animals
SCH-23390
Receptors, Dopamine D2
Receptors, Dopamine D1
Antagonist
Benzazepines
Rats
030227 psychiatry
Delay Discounting
nervous system
chemistry
Competitive antagonist
Impulsive Behavior
NMDA receptor
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Psychology
Reinforcement, Psychology
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 19390084 and 07357044
- Volume :
- 131
- Database :
- OpenAIRE
- Journal :
- Behavioral Neuroscience
- Accession number :
- edsair.doi.dedup.....8506950da5278a5b917bd8e6e7a4e505