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Assessor- and participant-blinded, randomized controlled trial of dense cranial electroacupuncture stimulation plus body acupuncture for neuropsychiatric sequelae of stroke
- Source :
- Psychiatry and clinical neurosciencesReferences. 74(3)
- Publication Year :
- 2019
-
Abstract
- Aim Acupuncture has benefits in the rehabilitation of neuropsychiatric sequelae of stroke. This study was aimed to evaluate the effectiveness of dense cranial electroacupuncture stimulation plus body acupuncture (DCEAS+BA) in treating poststroke depression (PSD), functional disability, and cognitive deterioration. Methods In this assessor- and participant-blinded, randomized controlled trial, 91 stroke patients who initially had PSD were randomly assigned to either DCEAS+BA (n = 45) or minimum acupuncture stimulation as controls (n = 46) for three sessions per week over 8 consecutive weeks. The primary outcome was baseline-to-end-point change in score of the 17-item Hamilton Depression Rating Scale. Secondary outcomes included the Montgomery-Asberg Depression Rating Scale for depressive symptoms, the Barthel Index for functional disability, and the Montreal Cognitive Assessment for cognitive function. Results DCEAS+BA-treated patients showed strikingly greater end-point reduction than MAS-treated patients in scores of the three symptom domains. The clinical response rate, defined as an at least 50% baseline-to-end-point reduction in 17-item Hamilton Depression Rating Scale score, was markedly higher in the DCEAS+BA-treated group than that of controls (40.0% vs 17.4%, P = 0.031). Incidence of adverse events was not different in the two groups. Subgroup analysis revealed that DCEAS+BA with electrical stimulation on forehead acupoints was more apparent in reducing Barthel-Index-measured disability than that without electrical stimulation. Conclusion DCEAS+BA, particularly with electrical stimulation on forehead acupoints, reduces PSD, functional disability, and cognitive deterioration of stroke patients. It can serve as an effective rehabilitation therapy for neuropsychiatric sequelae of stroke.
- Subjects :
- Male
medicine.medical_specialty
Electroacupuncture
medicine.medical_treatment
Acupuncture Therapy
Severity of Illness Index
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
Double-Blind Method
law
Acupuncture
Medicine
Post-stroke depression
Humans
Cognitive Dysfunction
Forehead
Stroke
Depression (differential diagnoses)
Aged
Rehabilitation
business.industry
Depression
General Neuroscience
Skull
Stroke Rehabilitation
Montreal Cognitive Assessment
Extremities
General Medicine
Middle Aged
medicine.disease
030227 psychiatry
Psychiatry and Mental health
Outcome and Process Assessment, Health Care
Neurology
Physical therapy
Female
Neurology (clinical)
business
Acupuncture Points
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14401819
- Volume :
- 74
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Psychiatry and clinical neurosciencesReferences
- Accession number :
- edsair.doi.dedup.....850662283a954260f25cf78d770a6a29