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Action of surface-active substances on biological membranes. IV. Hemolytic and membrane-perturbing action of homologous series of beta-D-glucopyranosyl-1-alkylphosphates
- Source :
- Biochimica et biophysica acta. 556(2)
- Publication Year :
- 1979
-
Abstract
- The hemolytic action of a homologous series of beta-D-glucopyranosyl-1-alkylphosphates on human erythrocytes has been examined. The agent's affinity for the red cell membrane and the mean number of the agent's molecules which, upon interaction with an erythrocyte, make it undergo hemolysis have been measured. The contribution of the head group and that of a CH2 group of the surfactants to the free energy of the agents' binding to the cell membrane have been estimated. The effect of the surfactants on the red cell volume and the lytic concentrations of the agents have been measured. The contribution of a CH2 group to the free energy of the interaction of the amphiphiles embedded in the membrane bilayer with their environment has been evaluated and is proposed to be used as a measure of the membrane matrix stability.
- Subjects :
- Lysis
Erythrocytes
Chemistry
Stereochemistry
Bilayer
Erythrocyte Membrane
Biophysics
Glucosephosphates
Biological membrane
Cell Biology
medicine.disease
Biochemistry
Hemolysis
Cell membrane
Homologous series
chemistry.chemical_compound
Surface-Active Agents
medicine.anatomical_structure
Membrane
Amphiphile
medicine
Humans
Thermodynamics
Erythrocyte Volume
Subjects
Details
- ISSN :
- 00063002
- Volume :
- 556
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Biochimica et biophysica acta
- Accession number :
- edsair.doi.dedup.....84e7ad425f7501f55057d9eda707de54