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Investigation of colorectal cancer in accordance with consensus molecular subtype classification
- Source :
- Annals of Gastroenterological Surgery, Vol 4, Iss 5, Pp 528-539 (2020), Annals of Gastroenterological Surgery
- Publication Year :
- 2020
-
Abstract
- The classification of colorectal cancer (CRC) plays a pivotal role in predicting a patient's prognosis and determining treatment strategies. The consensus molecular subtype (CMS) classification system was constructed by analyzing genetic information from 18 CRC data sets, containing 4151 CRC samples. CRC was classified into four subtypes with distinct molecular and biological characteristics: CMS1 (microsatellite instability immune), CMS2 (canonical), CMS3 (metabolic), and CMS4 (mesenchymal). Since their designation in 2015, these classifications have been applied to basic and translational research of CRC, with the hope that understanding these subsets will influence a clinician's approach to therapeutic treatment and improve clinical outcomes. We reviewed CRC investigations in accordance with CMSs published in the last 5 years to further explore the clinical significance of these subtypes and identify underlying trends that may direct relevant future research. We determined that CMSs linked common features of CRC cell lines and PDX models in various studies. Furthermore, associations between prognosis and clinicopathological findings, including pathological grade and the stage of carcinogenesis, tumor budding, and tumor location, were correlated with CMS classification. Novel prognostic factors were identified, and the relationship between chemotherapeutic drug resistance and CMS has been fortified by our compilation of research; thus, indicating that this review provides advanced insight into clinical questions and treatment strategies for CRC.<br />CRC was classified into four subtypes with distinct molecular and biological characteristics: CMS1 (microsatellite instability immune), CMS2 (canonical), CMS3 (metabolic), and CMS4 (mesenchymal). Novel prognostic factors were identified, and the relationship between chemotherapeutic drug resistance and CMS has been fortified by our compilation of research.
- Subjects :
- Oncology
medicine.medical_specialty
RD1-811
Colorectal cancer
Translational research
colorectal cancer
Review Article
RC799-869
medicine.disease_cause
Tumor budding
Internal medicine
medicine
Clinical significance
Stage (cooking)
Review Articles
Pathological
business.industry
Gastroenterology
Microsatellite instability
Diseases of the digestive system. Gastroenterology
medicine.disease
digestive system diseases
Surgery
consensus molecular subtype
business
Carcinogenesis
prognostic marker
Subjects
Details
- ISSN :
- 24750328
- Volume :
- 4
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Annals of gastroenterological surgery
- Accession number :
- edsair.doi.dedup.....84e5aeea00a517c4cdd232d4f8d50c51