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NEAT1 as a competing endogenous RNA in tumorigenesis of various cancers: Role, mechanism and therapeutic potential
- Source :
- International Journal of Biological Sciences
- Publication Year :
- 2021
- Publisher :
- Ivyspring International Publisher, 2021.
-
Abstract
- The nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) that is upregulated in a variety of human cancer types. Increasing evidence has shown that the elevation of NEAT1 in cancer cells promotes cell growth, migration, and invasion and inhibits cell apoptosis. It is also known that lncRNAs act as a competing endogenous RNA (ceRNA) by sponging microRNAs (miRNAs) to alter the expression levels of their target genes in the development of cancers. Therefore, it is important to understand the molecular mechanisms underlying this observation. In this review, specific emphasis was placed on NEAT1's role in tumor development. We also summarize and discuss the feedback roles of NEAT1/miRNA/target network in the progression of various cancers. As our understanding of the role of NEAT1 during tumorigenesis improves, its therapeutic potential as a biomarker and/or target for cancer also becomes clearer.
- Subjects :
- Carcinogenesis
NEAT1
Review
Biology
medicine.disease_cause
Applied Microbiology and Biotechnology
Neoplasms
microRNA
medicine
cancer
Humans
competing endogenous RNA
Molecular Biology
Ecology, Evolution, Behavior and Systematics
long non-coding RNA
Competing endogenous RNA
Cancer
RNA
therapeutic target
Paraspeckle
Cell Biology
medicine.disease
Long non-coding RNA
Biomarker (cell)
Gene Expression Regulation, Neoplastic
Cancer research
RNA, Long Noncoding
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 14492288
- Volume :
- 17
- Issue :
- 13
- Database :
- OpenAIRE
- Journal :
- International Journal of Biological Sciences
- Accession number :
- edsair.doi.dedup.....84e560aba48946c53d8f2a2493d8e1c0