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Presence and distribution of leucocyte subsets in the murine epididymis after vasectomy
- Source :
- International journal of andrology. 13(1)
- Publication Year :
- 1990
-
Abstract
- Summary Male mice were vasectomized by ‘open-ended’ or ‘closed’ techniques. After 4 weeks the cell-mediated immune reactions were compared with those of sham-operated animals by immunohistochemical localization of leucocytes, using specific monoclonal antibodies. Macrophages and MHC class II antigen-positive cells were the major cell types to appear in all regions of the epididymis after both types of operation. There was recruitment of T-helper/inducer leucocytes but not of T-suppressor-cytotoxic cells. An increased presentation of macrophage-migration inhibiting factor antigen appeared in interstitial and peritubular locations. After ‘closed’ and ‘open-ended’ vasectomy granulomata developed in the epididymis. The sperm-containing lumen of these granulomata was invaded by macrophages, MHC class II-positive cells and T-helper/inducer lymphocytes. This mouse model thus reveals a significant epididymal inflammatory response of the epididymis to vasectomy.
- Subjects :
- Male
medicine.drug_class
Urology
Endocrinology, Diabetes and Metabolism
T-Lymphocytes
Inflammation
Monoclonal antibody
Testicular Diseases
Andrology
Mice
Antigen
MHC class I
Vasectomy
medicine
Leukocytes
Animals
Macrophage Migration-Inhibitory Factors
Epididymis
MHC class II
Immunity, Cellular
Granuloma
biology
Macrophages
Histocompatibility Antigens Class II
Immunohistochemistry
medicine.anatomical_structure
Reproductive Medicine
biology.protein
medicine.symptom
Subjects
Details
- ISSN :
- 01056263
- Volume :
- 13
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- International journal of andrology
- Accession number :
- edsair.doi.dedup.....84d1f52024cabb0dad97b668b66a1799