Back to Search
Start Over
The Anti-Inflammatory Effects of a New Herbal Formula (WSY-1075) in a Nonbacterial Prostatitis Rat Model
- Source :
- The World Journal of Men's Health
- Publication Year :
- 2013
- Publisher :
- Korean Society for Sexual Medicine and Andrology, 2013.
-
Abstract
- Purpose: The aim of this study was to investigate the anti-inflammatory effects of a new herbal formula (WSY-1075) in a nonbacterial prostatitis rat model. Materials and Methods: Prostatitis was induced in male Wistar rats (n=32) by treatment with 17 beta-estradiol and dihydrotestosterone for 4 weeks. After the induction of prostatitis, the rats were randomly divided into one of four treatment groups: control (n=8), ciprofloxacin (n=8), WSY-1075 (100 mg/kg) (n=8), and WSY-1075 (400 mg/kg) (n=8). After 4 weeks of treatment, the prostatic proinflammatory cytokine (tumor necrosis factor-α, interleukin [IL]-6, and IL-8) levels and histological findings were noted. Results: The ciprofloxacin and WSY-1075 treatment groups showed significantly decreased proinflammatory cytokine levels compared with the control group. Histologically, treatment with ciprofloxacin and WSY-1075 significantly suppressed the severity of prostatitis lesions compared with those in the control group. No differences in the proinflammatory cytokine levels or histologic findings were observed with the dose dependent treatment of WSY-1075. Conclusions: The new herbal formula, WSY-1075, showed effective anti-inflammatory activities in the prostate and may be useful for the clinical treatment of nonbacterial prostatitis. Our findings suggest that WSY-1075 has a beneficial effect on the prevention and treatment of nonbacterial prostatitis.
- Subjects :
- Aging
medicine.medical_specialty
medicine.drug_class
Urology
Prostatitis
Gastroenterology
Anti-inflammatory
Proinflammatory cytokine
Prostate
Internal medicine
Medicine
Pharmacology (medical)
Inflammation
business.industry
Health Policy
Public Health, Environmental and Occupational Health
Interleukin
medicine.disease
Ciprofloxacin
Psychiatry and Mental health
Herbals
medicine.anatomical_structure
Reproductive Medicine
Dihydrotestosterone
Immunology
Original Article
Tumor necrosis factor alpha
business
medicine.drug
Subjects
Details
- ISSN :
- 22874690 and 22874208
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- The World Journal of Men's Health
- Accession number :
- edsair.doi.dedup.....84ceb7c315d7b8918c53ba5e20ec6677