Back to Search Start Over

The role of critical immune genes in brain disorders: insights from neuroimaging immunogenetics

Authors :
Beilei Bian
Baptiste Couvy-Duchesne
Naomi R. Wray
Allan F. McRae
Institute for Molecular Bioscience
University of Queensland [Brisbane]
Algorithms, models and methods for images and signals of the human brain (ARAMIS)
Sorbonne Université (SU)-Inria de Paris
Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut du Cerveau = Paris Brain Institute (ICM)
Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP]
Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP]
Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Institut du Cerveau = Paris Brain Institute (ICM)
Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Couvy-Duchesne, Baptiste
Source :
Brain Communications, Brain Communications, 2022, 4 (2), ⟨10.1093/braincomms/fcac078⟩
Publication Year :
2021

Abstract

Genetic variants in the human leukocyte antigen and killer cell immunoglobulin-like receptor regions have been associated with many brain-related diseases, but how they shape brain structure and function remains unclear. To identify the genetic variants in HLA and KIR genes associated with human brain phenotypes, we performed a genetic association study of ∼30 000 European unrelated individuals using brain MRI phenotypes generated by the UK Biobank (UKB). We identified 15 HLA alleles in HLA class I and class II genes significantly associated with at least one brain MRI-based phenotypes (P

Subjects

Subjects :
[SDV.GEN]Life Sciences [q-bio]/Genetics
Complement component 4
Human leukocyte antigen
Killer cell immunoglobulin-like receptor
Genetic association
General Engineering
Neuroimaging
[SDV.GEN] Life Sciences [q-bio]/Genetics

Details

ISSN :
26321297
Volume :
4
Issue :
2
Database :
OpenAIRE
Journal :
Brain communications
Accession number :
edsair.doi.dedup.....84c7831530fac4bc9d7dd50d62b8efa3

Tools

Authors Abstract Subjects Details