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Long-term assessment of systemic inflammation and the cumulative incidence of age-related hearing impairment in the epidemiology of hearing loss study
- Source :
- The journals of gerontology. Series A, Biological sciences and medical sciences. 69(2)
- Publication Year :
- 2013
-
Abstract
- Background Although research has linked systemic inflammation to various diseases of aging, few studies have examined the potential role it may play in the development of age-related hearing impairment. Methods Among 1,073 participants free of hearing impairment (pure-tone average 0.5, 1, 2, 4kHz ≤ 25 dB HL) in the population-based Epidemiology of Hearing Loss Study (1998-2000), serum C-reactive protein, and interleukin-6 were measured at three time points (1988-1990, 1998-2000, and 2009-2010), and tumor necrosis factor-α was measured at one time point (1998-2000), whereas hearing impairment was measured again in 2003-2005 and 2009-2010 to determine the 10-year cumulative incidence. Results Inflammatory marker levels from a single time point (1998-2000) were not associated with an increased risk of developing hearing impairment. Associations between long-term serum C-reactive protein levels and incident hearing impairment differed by age (p = .031). Participants less than 60 years with consistently high (>3 mg/L) or increasing levels of serum C-reactive protein over 10 years were nearly two times (hazard ratio: 1.96, 95% confidence interval: 1.19, 3.23) as likely to develop hearing impairment over the subsequent 10-year period, an association not seen in participants more than or equal to 60 years. A statistically significant association (p-trend = .041) was also observed between number of markers in the highest group at baseline and incident hearing impairment in this younger age group. Conclusions Associations between long-term serum C-reactive protein levels and incident hearing impairment were observed in the cohort as a whole, but differed significantly by age group, with statistically significant associations observed in adults less than 60 years, participants moving through the peak risk period for hearing impairment over the course of the study.
- Subjects :
- Male
Aging
medicine.medical_specialty
Time Factors
Hearing loss
Population
Presbycusis
Audiology
Cohort Studies
Risk Factors
Internal medicine
medicine
Humans
Cumulative incidence
education
Aged
Aged, 80 and over
Inflammation
education.field_of_study
business.industry
Interleukin-6
Tumor Necrosis Factor-alpha
Incidence (epidemiology)
Incidence
Hazard ratio
Age Factors
Middle Aged
medicine.disease
C-Reactive Protein
Cohort
Female
Geriatrics and Gerontology
medicine.symptom
business
Cohort study
Research Article
Subjects
Details
- ISSN :
- 1758535X
- Volume :
- 69
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- The journals of gerontology. Series A, Biological sciences and medical sciences
- Accession number :
- edsair.doi.dedup.....84c0d7d0fb73cadda08e360e39090bcb