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Scattering properties and femtosecond laser ablation thresholds of human and canine vocal folds at 776-nm wavelength
- Source :
- Journal of Biomedical Optics
- Publication Year :
- 2019
- Publisher :
- Society of Photo-Optical Instrumentation Engineers, 2019.
-
Abstract
- Ultrafast laser ablation may provide a treatment for vocal fold (VF) scarring. Optical properties of VFs must be known prior to clinical implementation to select appropriate laser surgery conditions. We present scattering lengths of epithelium ls , ep, superficial lamina propria ls , SLP, and ablation thresholds F th of human and canine VF tissues. Our experimental approach involves an image-guided, laser-ablation-based method that allows for simultaneous determination of ls and F th in these multilayered tissues. Studying eight canine samples, we found ls , ep = 75.3 ± 5.7 μm, ls , SLP = 26.1 ± 1.2 μm, F th , ep = 1.58 ± 0.06 J / cm2, and F th , SLP = 1.55 ± 0.17 J / cm2. Studying five human samples, we found ls , ep = 42.8 ± 3.3 μm and F th , ep = 1.66 ± 0.10 J / cm2. We studied the effects of cumulative pulse overlap on ablation threshold and found no significant variations beyond 12 overlapping pulses. Interestingly, our studies about the effect of sample storage on the scattering properties of porcine VF show a 60% increase in ls , ep for fresh porcine VF when compared to the same sample stored in isotonic solution. These results provide guidelines for clinical implementation by enabling selection of optimal laser surgery parameters for subsurface ablation of VF tissues.
- Subjects :
- Laser surgery
Paper
Materials science
Swine
medicine.medical_treatment
Biomedical Engineering
Vocal Cords
01 natural sciences
Specimen Handling
010309 optics
Biomaterials
Laryngeal Diseases
Cicatrix
Dogs
Species Specificity
vocal folds scarring
0103 physical sciences
ultrafast laser surgery
medicine
Animals
Humans
Scattering, Radiation
General
Laser ablation
Mucous Membrane
Scattering
Lasers
Ablation
Femtosecond laser ablation
Atomic and Molecular Physics, and Optics
Electronic, Optical and Magnetic Materials
Wavelength
vocal folds
medicine.anatomical_structure
tissue ablation, ultrafast lasers
Vocal folds
Laser Therapy
Ultrashort pulse
scattering measurements
Biomedical engineering
Subjects
Details
- Language :
- English
- ISSN :
- 15602281 and 10833668
- Volume :
- 24
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of Biomedical Optics
- Accession number :
- edsair.doi.dedup.....84c0464582de0219b5c06d89aefe3835