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RUNX1 point mutations potentially identify a subset of early immature T-cell acute lymphoblastic leukaemia that may originate from differentiated T-cells
- Source :
- Gene. 545:111-116
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- The RUNX1/AML1 gene is among the most frequently mutated genes in human leukaemia. However, its association with T-cell acute lymphoblastic leukaemia (T-ALL) remains poorly understood. In order to examine RUNX1 point mutations in T-ALL, we conducted an amplicon-based deep sequencing in 65 Southeast Asian childhood patients and 20 T-ALL cell lines, and detected RUNX1 mutations in 6 patients (9.2%) and 5 cell lines (25%). Interestingly, RUNX1-mutated T-ALL cases seem to constitute a subset of early immature T-ALL that may originate from differentiated T-cells. This result provides a deeper insight into the mechanistic basis for leukaemogenesis.
- Subjects :
- Male
Adolescent
Biology
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Southeast asian
Deep sequencing
Young Adult
chemistry.chemical_compound
Cell Line, Tumor
hemic and lymphatic diseases
Genetics
Humans
Point Mutation
Child
Gene
Sequence Deletion
Point mutation
T-cell acute lymphoblastic leukaemia
Genes, T-Cell Receptor gamma
Cell Differentiation
General Medicine
Amplicon
RUNX1
chemistry
Cell culture
Child, Preschool
Core Binding Factor Alpha 2 Subunit
embryonic structures
Immunology
Cancer research
Female
Subjects
Details
- ISSN :
- 03781119
- Volume :
- 545
- Database :
- OpenAIRE
- Journal :
- Gene
- Accession number :
- edsair.doi.dedup.....84bb02b978fa79fa91169f42fce24105