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A novel multicompartimental system based on aminated poly(vinyl alcohol) microspheres/succinoylated pullulan microspheres for oral delivery of anionic drugs
- Publication Year :
- 2007
-
Abstract
- Poly(vinyl alcohol) (PVA) microspheres were prepared by dispersion reticulation with glutaraldehyde and further aminated. These microspheres were firstly loaded with diclofenac (DF) and then entrapped in cellulose acetate butyrate (CAB) microcapsules by an o/w solvent evaporation technique for intestinal delivery of drug. The encapsulated PVA microspheres due to their low swelling degree in intestinal fluids, do not have enough force to produce the disruption of CAB shell, therefore different amounts of succinoylated pullulan microspheres (SP-Ms) (exchange capacity up to 5.2 meq/g) were co-encapsulated. The SP-Ms do not swell in acidic pH, but swell up to 20-times in intestinal fluids causing the rupture of CAB shell and facilitating the escape of loaded PVA microspheres.
- Subjects :
- Succinic Anhydrides
Vinyl alcohol
Diclofenac
Pharmaceutical Science
Capsules
Alcohol
drug delivery systems
chemistry.chemical_compound
multicompartimental systems
Polymer chemistry
medicine
Technology, Pharmaceutical
Microparticle
Cellulose
Ion-exchange resin
Glucans
integumentary system
Anti-Inflammatory Agents, Non-Steroidal
Succinates
ion exchange resin
microencapsulation
Pullulan
Microspheres
Kinetics
chemistry
Polyvinyl Alcohol
Microscopy, Electron, Scanning
Glutaraldehyde
Swelling
medicine.symptom
Drug carrier
Nuclear chemistry
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....84b9a2de298eb66f81dfb004e7479a59