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The Role of Platelets in Diabetic Kidney Disease
- Source :
- Rustiasari, U J & Roelofs, J J 2022, ' The Role of Platelets in Diabetic Kidney Disease ', International Journal of Molecular Sciences, vol. 23, no. 15, 8270 . https://doi.org/10.3390/ijms23158270
- Publication Year :
- 2022
-
Abstract
- Diabetic kidney disease (DKD) is among the most common microvascular complications in patients with diabetes, and it currently accounts for the majority of end-stage kidney disease cases worldwide. The pathogenesis of DKD is complex and multifactorial, including systemic and intra-renal inflammatory and coagulation processes. Activated platelets play a pivotal role in inflammation, coagulation, and fibrosis. Mounting evidence shows that platelets play a role in the pathogenesis and progression of DKD. The potentially beneficial effects of antiplatelet agents in preventing progression of DKD has been studied in animal models and clinical trials. This review summarizes the current knowledge on the role of platelets in DKD, including the potential therapeutic effects of antiplatelet therapies.
- Subjects :
- Blood Platelets
Inflammation
diabetes
diabetic nephropathy
Organic Chemistry
General Medicine
antiplatelet
Kidney
Catalysis
diabetic kidney disease
Computer Science Applications
Inorganic Chemistry
platelets
platelet activation
Diabetes Mellitus
biomarker
Animals
Kidney Failure, Chronic
Diabetic Nephropathies
Physical and Theoretical Chemistry
Molecular Biology
Spectroscopy
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 23
- Issue :
- 15
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....84b395469c1a823bdeea9d7f3b40bebc
- Full Text :
- https://doi.org/10.3390/ijms23158270