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CD36 in Atherosclerosis: Pathophysiological Mechanisms and Therapeutic Implications
- Source :
- Current Atherosclerosis Reports. 22
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Atherosclerosis is a chronic disease characterized by lipid retention and inflammation in the artery wall. The retention and oxidation of low-density lipoprotein (LDL) in sub-endothelial space play a critical role in atherosclerotic plaque formation and destabilization. Oxidized LDL (ox-LDL) and other modified LDL particles are avidly taken up by endothelial cells, smooth muscle cells, and macrophages mainly through several scavenger receptors, including CD36 which is a class B scavenger receptor and membrane glycoprotein. Animal studies performed on CD36-deficient mice suggest that deficiency of CD36 prevents the development of atherosclerosis, though with some debate. CD36 serves as a signaling hub protein at the crossroad of inflammation, lipid metabolism, and fatty acid metabolism. In addition, the level of soluble CD36 (unattached to cells) in the circulating blood was elevated in patients with atherosclerosis and other metabolic disorders. We performed a state-of-the-art review on the structure, ligands, functions, and regulation of CD36 in the context of atherosclerosis by focusing on the pathological role of CD36 in the dysfunction of endothelial cells, smooth muscle cells, monocytes/macrophages, and platelets. Finally, we highlight therapeutic possibilities to target CD36 expression/activity in atherosclerosis.
- Subjects :
- CD36 Antigens
CD36
Myocytes, Smooth Muscle
Inflammation
030204 cardiovascular system & hematology
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
parasitic diseases
medicine
Animals
Humans
Macrophage
030212 general & internal medicine
Scavenger receptor
Fatty acid metabolism
biology
business.industry
Macrophages
Endothelial Cells
Lipid metabolism
Atherosclerosis
Platelet Activation
Plaque, Atherosclerotic
Lipoproteins, LDL
Endothelial stem cell
Cholesterol
chemistry
Cancer research
biology.protein
Hydroxymethylglutaryl-CoA Reductase Inhibitors
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Signal Transduction
Lipoprotein
Subjects
Details
- ISSN :
- 15346242 and 15233804
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Current Atherosclerosis Reports
- Accession number :
- edsair.doi.dedup.....84ad96756d8c7ebc5df4cb84b588b006