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Gabor optical coherence tomographic angiography (GOCTA) (Part II): theoretical basis of sensitivity improvement and optimization for processing speed
- Source :
- Biomedical Optics Express. 11:227
- Publication Year :
- 2019
- Publisher :
- Optica Publishing Group, 2019.
-
Abstract
- We previously proposed a Gabor optical coherence tomography angiography (GOCTA) algorithm for spectral domain optical coherence tomography (SDOCT) to extract microvascular signals from spectral fringes directly, with speed improvement of 4 to 20 times over existing methods. In this manuscript, we explored the theoretical basis of GOCTA with comparison of experimental data using solid and liquid displacement sample targets, demonstrating that the majority of the GOCTA sensitivity advantage over speckle variance based techniques was in the small displacement range (< 10 ∼ 20 µm) of the moving target (such as red blood cells). We further normalized GOCTA signal by root-mean-square (RMS) of original fringes, achieving a more uniform image quality, especially at edges of blood vessels where slow flow could occur. Furthermore, by transecting the spectral fringes and using skipped convolution, the data processing speed could be further improved. We quantified the trade-off in signal-to-noise-ratio (SNR) and contrast-to-noise-ratio (CNR) under various sub-spectral bands and found an optimized condition using 1/4 spectral band for minimal angiography image quality degradation, yet achieving a further 26.7 and 34 times speed improvement on GPU and CPU, respectively. Our optimized GOCTA algorithm has a speed advantage of over 140 times compared to existing speckle variance OCT (SVOCT) method.
- Subjects :
- Physics
0303 health sciences
medicine.diagnostic_test
Image quality
business.industry
Image processing
Spectral bands
01 natural sciences
Article
Atomic and Molecular Physics, and Optics
Convolution
010309 optics
03 medical and health sciences
Speckle pattern
Optics
Optical coherence tomography
0103 physical sciences
medicine
Optical Doppler Tomography
business
030304 developmental biology
Biotechnology
Coherence (physics)
Subjects
Details
- ISSN :
- 21567085
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Biomedical Optics Express
- Accession number :
- edsair.doi.dedup.....84a959133942bedb612f93933cb3ad19