Back to Search
Start Over
Clinical and Functional Lung Parameters Associated With Frequent Exacerbator Phenotype in Subjects With Severe COPD
- Source :
- Respiratory Care. 62:572-578
- Publication Year :
- 2017
- Publisher :
- Daedalus Enterprises, 2017.
-
Abstract
- BACKGROUND: COPD is currently recognized as a syndrome associated with a high prevalence of comorbidities and various phenotypes. Exacerbations are very important events in the clinical history of COPD because they drive the decline in lung function. In the present study, we aim to identify whether there are any clinical and functional specific features of frequent exacerbators in a population of patients with severe COPD. METHODS: We conducted a cross-sectional, case control study. All subjects had Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage 3 or 4 COPD (FEV 1 n = 183) reported ≥2 exacerbations or ≥1 determining hospitalization during the previous 12 months, and infrequent exacerbators ( n = 162) reported RESULTS: Frequent exacerbators had a significantly lower inspiratory capacity percentage predicted. The Motley index (residual volume/total lung capacity percentage) was significantly increased in frequent exacerbators. Infrequent exacerbators had lower Modified Medical Research Council dyspnea scale and BODE index than frequent exacerbators. In the multivariate model, a reduced inspiratory capacity percentage predicted and an increase of residual volume/total lung capacity percentage, BODE index and Modified Medical Research Council dyspnea scale were associated with the frequent exacerbation phenotype. CONCLUSIONS: Static hyperinflation and respiratory disability, measured by Motley index and Modified Medical Research Council dyspnea scale, respectively, in the same way as the multidimensional BODE index staging system, were independently associated with frequent exacerbation status in subjects with severe COPD.
- Subjects :
- Adult
Male
Pulmonary and Respiratory Medicine
BODE index
Spirometry
medicine.medical_specialty
Exacerbation
Population
Critical Care and Intensive Care Medicine
Severity of Illness Index
Pulmonary Disease, Chronic Obstructive
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
Lung volumes
030212 general & internal medicine
education
Intensive care medicine
Lung
Aged
COPD
education.field_of_study
medicine.diagnostic_test
business.industry
Total Lung Capacity
Respiratory disease
General Medicine
Middle Aged
medicine.disease
Obstructive lung disease
respiratory tract diseases
Residual Volume
Cross-Sectional Studies
Logistic Models
Phenotype
030228 respiratory system
Case-Control Studies
Disease Progression
Female
business
Subjects
Details
- ISSN :
- 19433654 and 00201324
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Respiratory Care
- Accession number :
- edsair.doi.dedup.....84a562e42d3907be8317954f36105dac