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Different Effects of Pueraria mirifica, a Herb Containing Phytoestrogens, on LH and FSH Secretion in Gonadectomized Female and Male Rats
- Source :
- Journal of Pharmacological Sciences, Vol 96, Iss 4, Pp 428-435 (2004)
- Publication Year :
- 2004
- Publisher :
- Elsevier, 2004.
-
Abstract
- To investigate the effect of Pueraria mirifica (P. mirifica) containing phytoestrogens on reproductive systems, both sexes of rats were gonadectomized and treated orally with 0, 10, 100, and 1,000 mg/kg BW per day of P. mirifica suspended in water (abbreviated as P-0, P-10, P-100, and P-1000), respectively. The treatment schedule was separated into 3 periods: pre-treatment, treatment, and post-treatment. The duration for each period was 14 days. Blood samples were taken once a week. Serum LH and FSH levels were significantly increased within 1 week after gonadectomy; and there were no changes after administration of P-0, P-10, and P-100. However, the increase of LH levels in both sexes and FSH levels in females were attenuated within 1 week after P-1,000 treatment. The attenuation of LH levels in males was smaller than that of females. The decrease of gonadotropin levels was recovered within 1 week in males and 2 weeks in females, respectively, during the post-treatment period. The increase of uterine weight and vaginal cornification were observed in female rats treated with P-100 and P-1,000, whereas only the increase of epididymis weight was found in male rats treated with P-1,000. From this study, it can be concluded that P. mirifica can influence the reproductive functions in both sexes of rats, but the response in females is greater than in males. Keywords:: Pueraria mirifica, phytoestrogen, LH, FSH, vaginal cytology
- Subjects :
- Male
medicine.medical_specialty
Pueraria
medicine.drug_class
Phytoestrogens
Kidney
Follicle-stimulating hormone
chemistry.chemical_compound
Sex Factors
Internal medicine
medicine
Animals
Castration
Genitalia
Rats, Wistar
Pharmacology
Vaginal Smears
biology
lcsh:RM1-950
Organ Size
Luteinizing Hormone
biology.organism_classification
Miroestrol
Rats
Endocrinology
lcsh:Therapeutics. Pharmacology
chemistry
Liver
Molecular Medicine
Female
Gonadotropin
Follicle Stimulating Hormone
Luteinizing hormone
Pueraria mirifica
Subjects
Details
- Language :
- English
- ISSN :
- 13478613
- Volume :
- 96
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmacological Sciences
- Accession number :
- edsair.doi.dedup.....84a1f635d261c8358a88c843d7c2f1b7