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Risk Factors for Seizures Among Young Children Monitored With Continuous Electroencephalography in Intensive Care Unit: A Retrospective Study
- Source :
- Frontiers in Pediatrics, Frontiers in Pediatrics, Vol 6 (2018)
- Publication Year :
- 2018
-
Abstract
- Objective: cEEG is an emerging technology for which there are no clear guidelines for patient selection or length of monitoring. The purpose of this study was to identify subgroups of pediatric patients with high incidence of seizures. Study Design: We conducted a retrospective study on 517 children monitored by cEEG in the intensive care unit (ICU) of a children's hospital. The children were stratified using an age threshold selection method. Using regression modeling, we analyzed significant risk factors for increased seizure risk in younger and older children. Using two alternative correction procedures, we also considered a relevant comparison group to mitigate selection bias and to provide a perspective for our findings. Results: We discovered an approximate risk threshold of 14 months: below this threshold, the seizure risk increases dramatically. The older children had an overall seizure rate of 18%, and previous seizures were the only significant risk factor. In contrast, the younger children had an overall seizure rate of 45%, and the seizures were significantly associated with hypoxic-ischemic encephalopathy (HIE; p = 0.007), intracranial hemorrhage (ICH; p = 0.005), and central nervous system (CNS) infection (p = 0.02). Children with HIE, ICH, or CNS infection accounted for 61% of all seizure patients diagnosed through cEEG under 14 months. Conclusions: An extremely high incidence of seizures prevails among critically ill children under 14 months, particularly those with HIE, ICH, or CNS infection.
- Subjects :
- Pediatrics
medicine.medical_specialty
Continuous electroencephalography
media_common.quotation_subject
Encephalopathy
law.invention
03 medical and health sciences
0302 clinical medicine
law
030225 pediatrics
Intensive care
medicine
Risk threshold
media_common
Original Research
intensive care
Selection bias
non-convulsive
business.industry
lcsh:RJ1-570
lcsh:Pediatrics
Retrospective cohort study
medicine.disease
brain injury
Intensive care unit
pediatric
continuous EEG
Pediatrics, Perinatology and Child Health
Selection method
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 22962360
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Frontiers in pediatrics
- Accession number :
- edsair.doi.dedup.....849ca76e14e7e09efafc00136b26e02f