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Endoplasmic reticulum stress in health and disease
- Source :
- Current Opinion in Cell Biology. 18:444-452
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- Unfolded proteins and other conditions affecting endoplasmic reticulum (ER) homeostasis cause ER stress. The cell reacts to ER stress by activation of the unfolded protein response (UPR), which induces profound changes in cellular metabolism including general translation attenuation, transcriptional upregulation of molecular chaperone genes, and activation of ER-associated degradation. However, prolonged or acute ER stress results in cell death. Recent progress suggests that ER stress and UPR play key roles in the immune response, diabetes, tumor growth under hypoxic conditions, and in some neurodegenerative diseases. Further research on ER stress and UPR will greatly enhance the understanding of these physiological and pathological processes, and provide novel avenues to potential therapies.
- Subjects :
- Protein Folding
Endoplasmic reticulum
Cell
Models, Immunological
Neurodegenerative Diseases
Translation (biology)
Cell Biology
Disease
Biology
Endoplasmic Reticulum
Cell biology
medicine.anatomical_structure
Immune system
Downregulation and upregulation
Diabetes Mellitus
Unfolded protein response
medicine
Animals
Humans
Homeostasis
Subjects
Details
- ISSN :
- 09550674
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Cell Biology
- Accession number :
- edsair.doi.dedup.....849b64c63f8af3f87c60818c41c35de8