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Diagnosis of atrophic body gastritis in Chinese patients by measuring serum pepsinogen
- Source :
- Chinese journal of digestive diseases. 5(1)
- Publication Year :
- 2004
-
Abstract
- OBJECTIVE: Atrophic body gastritis (ABG) is common in China. Although histology via endoscopy is an efficient and reliable means of diagnosing ABG, it is an invasive procedure. Therefore, in the present study serum pepsinogen (PG) was used as a biomarker to develop a novel noninvasive test as the first option for screening of ABG in certain groups of Chinese. METHODS: The study population consisted of 81 selected dyspeptic patients (mean age, 64.8 ± 0.7 years; M:F, 43:38) who underwent diagnostic gastroscopy. At least four biopsy specimens were taken from the antrum and corpus of the stomach (two specimens from each site) for histological diagnosis. Blood samples for ELISA assays of serum pepsinogen I (PGI), pepsinogen II (PGII) and IgG antibodies against Helicobacter pylori (Hp IgG) were drawn after endoscopy. Cut-off points were calculated using receiver operating curves (ROC). RESULTS: There was no correlation between serum PG and atrophy in the antral mucosa. The mean serum concentration of PGI was lower (P
- Subjects :
- Gastritis, Atrophic
Male
medicine.medical_specialty
Pathology
Atrophic gastritis
Biopsy
Gastroenterology
Sensitivity and Specificity
Helicobacter Infections
Atrophy
Pepsin
Internal medicine
Gastroscopy
medicine
Pyloric Antrum
Humans
Antrum
Aged
biology
medicine.diagnostic_test
Helicobacter pylori
Pepsinogens
business.industry
Stomach
Middle Aged
medicine.disease
biology.organism_classification
Antibodies, Bacterial
medicine.anatomical_structure
ROC Curve
Gastric Mucosa
Immunoglobulin G
biology.protein
lipids (amino acids, peptides, and proteins)
Female
Gastritis
medicine.symptom
business
Biomarkers
Subjects
Details
- ISSN :
- 14439611
- Volume :
- 5
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Chinese journal of digestive diseases
- Accession number :
- edsair.doi.dedup.....849b5c2ba07ab0d79fd2d450d8752672