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A patient with rheumatoid arthritis treated with tocilizumab together with lamivudine prophylaxis after remission of infliximab-reactivated hepatitis B

Authors :
Hideki Tsuboi
Eiji Takeuchi
Kiyoshi Kawano
Akihide Nampei
Kenrin Shi
Harumasa Yoshihara
Akira Tsujii
Source :
Modern Rheumatology. 21:701-705
Publication Year :
2011
Publisher :
Oxford University Press (OUP), 2011.

Abstract

A 59-year-old woman with rheumatoid arthritis was treated quite successfully with infliximab, but her serum aminotransferase levels were markedly elevated; this was diagnosed as acute exacerbation of hepatitis B and she was treated with lamivudine, and infliximab was discontinued. The rheumatoid arthritis disease activity was uncontrollable after the discontinuation of infliximab, and we therefore initiated tocilizumab treatment (after obtaining the patient's informed consent) together with lamivudine prophylaxis. After tocilizumab administration her rheumatoid arthritis disease activity was significantly attenuated, and the activity has remained low, without re-exacerbation of the hepatitis, for more than 2 years since the initiation of the tocilizumab.

Details

ISSN :
14397609 and 14397595
Volume :
21
Database :
OpenAIRE
Journal :
Modern Rheumatology
Accession number :
edsair.doi.dedup.....848ac1efc1683753feca994e35c4ef72
Full Text :
https://doi.org/10.1007/s10165-011-0470-3