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A patient with rheumatoid arthritis treated with tocilizumab together with lamivudine prophylaxis after remission of infliximab-reactivated hepatitis B
- Source :
- Modern Rheumatology. 21:701-705
- Publication Year :
- 2011
- Publisher :
- Oxford University Press (OUP), 2011.
-
Abstract
- A 59-year-old woman with rheumatoid arthritis was treated quite successfully with infliximab, but her serum aminotransferase levels were markedly elevated; this was diagnosed as acute exacerbation of hepatitis B and she was treated with lamivudine, and infliximab was discontinued. The rheumatoid arthritis disease activity was uncontrollable after the discontinuation of infliximab, and we therefore initiated tocilizumab treatment (after obtaining the patient's informed consent) together with lamivudine prophylaxis. After tocilizumab administration her rheumatoid arthritis disease activity was significantly attenuated, and the activity has remained low, without re-exacerbation of the hepatitis, for more than 2 years since the initiation of the tocilizumab.
- Subjects :
- musculoskeletal diseases
medicine.medical_specialty
Arthritis
Antibodies, Monoclonal, Humanized
Gastroenterology
Arthritis, Rheumatoid
chemistry.chemical_compound
Tocilizumab
Rheumatology
Recurrence
Internal medicine
medicine
Humans
skin and connective tissue diseases
Hepatitis
business.industry
Antibodies, Monoclonal
Lamivudine
Middle Aged
Hepatitis B
medicine.disease
Infliximab
Treatment Outcome
chemistry
Antirheumatic Agents
Rheumatoid arthritis
Immunology
Reverse Transcriptase Inhibitors
Drug Therapy, Combination
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 14397609 and 14397595
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Modern Rheumatology
- Accession number :
- edsair.doi.dedup.....848ac1efc1683753feca994e35c4ef72
- Full Text :
- https://doi.org/10.1007/s10165-011-0470-3