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Sub-maximal aerobic exercise training reduces haematocrit and ameliorates symptoms in Andean highlanders with chronic mountain sickness
- Source :
- Experimental physiology. 106(11)
- Publication Year :
- 2021
-
Abstract
- New Findings: What is the central question of this study? What is the effect of sub-maximal aerobic exercise training on signs and symptoms of chronic mountain sickness (CMS) in Andean highlanders? What is the main finding and its importance? Aerobic exercise training (ET) effectively reduces haematocrit, ameliorates symptoms and improves aerobic capacity in CMS patients, suggesting that a regular aerobic ET programme might be used as a low-cost non-invasive/non-pharmacological management strategy of this syndrome. Abstract: Excessive erythrocytosis is the hallmark sign of chronic mountain sickness (CMS), a debilitating syndrome associated with neurological symptoms and increased cardiovascular risk. We have shown that unlike sedentary residents at the same altitude, trained individuals maintain haematocrit within sea-level range, and thus we hypothesise that aerobic exercise training (ET) might reduce excessive haematocrit and ameliorate CMS signs and symptoms. Eight highlander men (38 ± 12 years) with CMS (haematocrit: 70.6 ± 1.9%, CMS score: 8.8 ± 1.4) from Cerro de Pasco, Peru (4340 m) participated in the study. Baseline assessment included haematocrit, CMS score, pulse oximetry, maximal cardiopulmonary exercise testing and in-office plus 24 h ambulatory blood pressure (BP) monitoring. Blood samples were collected to assess cardiometabolic, erythropoietic, and haemolysis markers. ET consisted of pedalling exercise in a cycloergometer at 60% of (Formula presented.) for 1 h/day, 4 days/week for 8 weeks, and participants were assessed at weeks 4 and 8. Haematocrit and CMS score decreased significantly by week 8 (to 65.6 ± 6.6%, and 3.5 ± 0.8, respectively, P
- Subjects :
- Male
Physiology
Altitude Sickness
high density lipoprotein cholesterol
Andean highlanders
Peruvian
Medicine
excessive erythrocytosis
health care economics and organizations
chronic mountain sickness
clinical article
Nutrition and Dietetics
medicine.diagnostic_test
adult
Altitude
General Medicine
Effects of high altitude on humans
Blood Pressure Monitoring, Ambulatory
Haemolysis
pulse oximetry
Chronic mountain sickness
aerobic exercise
Hematocrit
hemodilution
Cardiology
cardiopulmonary exercise test
medicine.medical_specialty
Ambulatory blood pressure
hematocrit
Plasma volume
Article
male
Physiology (medical)
Internal medicine
high altitude
erythrocytosis
Aerobic exercise
Humans
human
Exercise
Aerobic capacity
plasma volume
business.industry
medicine.disease
aerobic capacity
blood pressure monitoring
Pulse oximetry
Chronic Disease
peak oxygen uptake
hemolysis
business
exercise training
Monge´s disease
Subjects
Details
- ISSN :
- 1469445X
- Volume :
- 106
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Experimental physiology
- Accession number :
- edsair.doi.dedup.....847618645678f1a3be6402cd4e955e0a