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Serum Tumor Markers in Stage I-II Breast Cancer
- Source :
- Scopus-Elsevier, Europe PubMed Central
- Publication Year :
- 2016
- Publisher :
- Bentham Science Publishers Ltd., 2016.
-
Abstract
- The prognosis of breast cancer is strongly influenced by the stage of the disease; therefore, it is essential that breast cancer lesions be diagnosed at the earliest stages. There is an urgent need to identify different biomarkers with a high accuracy for the early detection of this cancer to facilitate clinical management of the disease. A wide number of substances named serum tumor markers can be detected in the serum of patients with breast cancer, including tumor-associated proteins, cytokines, stimulating or inhibiting factors, autoantibodies to antigen tumor-associated substances and miRNAs. Despite ASCO and NACB recommendations, the routine use of breast cancer tumor markers by a significant proportion of oncologists is common, particularly after primary treatment of early tumors. The new promising circulating markers are HER2/neu, Trx 1, CSF1, autoantibodies against these tumor-associated antigens, and miRNAs, which are non-coding RNA molecules that regulate the translation of mRNA and control a number of biological processes, including oncogenic cells proliferation. The expression of single miRNA results in a miRNA signature, and is considered a potential biomarker for early breast cancer. However, additional studies are needed to identify its real usefulness.
- Subjects :
- CA15-3
Breast Neoplasms
Disease
Malignancy
Bioinformatics
03 medical and health sciences
breast cancer
0302 clinical medicine
Breast cancer
Antigen
HER2
CSF1
0502 economics and business
Drug Discovery
microRNA
Biomarkers, Tumor
Humans
Medicine
Trx1
early breast cancer
breast
Cancer
Neoplasm Staging
breast diseases
business.industry
05 social sciences
MicroRNA
030206 dentistry
medicine.disease
serum tumor markers
breast cancer treatment
Cancer research
Cancer, malignancy, breast, breast cancer, breast diseases, early breast cancer, breast cancer treatment, biomarker, serum tumor markers, ELISA, HER2, Trx1, CSF1, MicroRNA, HER2
biomarker
Biomarker (medicine)
ELISA
Female
050211 marketing
business
malignancy
Subjects
Details
- ISSN :
- 15734064
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....846d1ea71fa56a6c22c44b08d2264968