Back to Search
Start Over
Management of periorbital hyperpigmentation: An overview of nature-based agents and alternative approaches
- Source :
- Dermatologic therapyREFERENCES. 33(4)
- Publication Year :
- 2020
-
Abstract
- Periorbital hyperpigmentation (POH) is a common dermatological condition that presents as dark periorbital area beneath the lower eyelids, and it is commonly found in females belonging to the age group of 16 to 45 years. The data presented in this review include studies conducted on patients with a clinical/histological diagnosis of POH or melasma. Many diverse topical depigmenting agents comprising an array of naturally obtained actives such as arabinoxylans, α-arbutin, asiaticoside, azelaic acid, beta-carotene, boswellic acid, caffeine, chrysin, curcumin, cyanidin-3-glucoside, d-glucoronic acid, dihydrochalcone, dipalmitoyl-hydroxyprolene, fucoxanthin, genistein, glabridin, b-glucogallin, hyaluronic acid, lactic acid, lycopene, niacinamide, pycnogenol, retinol, salidroside, and xymenynic acid demonstrated significant benefits in the management of POH. An exhaustive literature search revealed that other techniques such as blepharoplasty, carboxytherapy, calcium hydroxylapatite fillers, tear trough implant, Q-switched ruby laser, medicated tattoo, fat transfer, micro-needling, chemical peels, nitrogen plasma skin regeneration, intense pulsed light, and radiofrequency have been evaluated and reported to be beneficial in the treatment of POH. The use of topical depigmenting agents is the most widely reported method in the clinical management of POH. Of these, α-arbutin, caffeine, cyanidin-3-glucoside, and dihydrochalcone are reported to exhibit significant benefits. Combination products containing a blend of actives are reported to be better than single active containing products. This review aims to provide a comprehensive perspective on the role of several topical actives in the modulation of melanin and tyrosinase biosynthesis pathway involved in the complex pathophysiology of POH. It also presents the advantages of combination products and other alternative therapies used in the management of POH.
- Subjects :
- Adult
Blepharoplasty
Periorbital hyperpigmentation
Azelaic acid
Adolescent
Melasma
medicine.medical_treatment
Dermatology
Intense pulsed light
Pharmacology
Melanosis
030207 dermatology & venereal diseases
03 medical and health sciences
chemistry.chemical_compound
Young Adult
0302 clinical medicine
Chemexfoliation
Hyperpigmentation
medicine
Humans
business.industry
Eyelids
Dihydrochalcone
General Medicine
Middle Aged
medicine.disease
chemistry
030220 oncology & carcinogenesis
Curcumin
Boswellic acid
Female
business
Glabridin
medicine.drug
Subjects
Details
- ISSN :
- 15298019
- Volume :
- 33
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Dermatologic therapyREFERENCES
- Accession number :
- edsair.doi.dedup.....845200fe2243c282811a7d329f9370f4