Class-switch recombination in extrachromosomal DNA substrates in murine pre-B-cells

BMR correlated, as expected, with lean body weight in both males (r=0.66, P>0.05) and females (r=0.91, P > 0.00 l ) , and almost attained a significant correlation with age in females. BMR also correlated with outputs of glucose and bilirubin in females (r=0.45 and 0.48, respectively; P < 0.05) and with protein output in both males and females ( r = 0.52 and 0.50, respectively; P < 0.025). Overall, no significant correlations were found for BMR and whole body measures of oxidant damage (MDA and MTA) in this pilot study. Further work is underway in this laboratory to establish possible interrelationships between BMR, oxidant damage, antioxidant status and the inflammatory response in larger groups of healthy adults as well as in aged groups and in patients in whom particular diseases have been diagnosed. 1. 2.