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Nab-paclitaxel plus S-1 with or without PD-1 inhibitor in pancreatic ductal adenocarcinoma with only hepatic metastases: a retrospective cohort study
- Source :
- Langenbeck's Archives of Surgery. 407:633-643
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- The evidence regarding programmed cell death 1 (PD-1) inhibitors on pancreatic ductal adenocarcinoma (PDAC) with metastases remains controversial. This study aimed to assess the efficacy and safety of Nab-paclitaxel plus S1 (NPS) with or without Sintilimab, a PD-1 inhibitor, in patients with PDAC with only hepatic metastases (mPDAC). Untreated mPDAC patients who received NPS with (the combination group) or without Sintilimab (the NPS group) were retrospectively studied. Surgery was considered when the pancreatic tumor became resectable or borderline resectable on radiological examinations, and with complete metabolic response of liver metastases. Between October 2017 and February 2020, 32 patients were in the combination group and 34 patients in the NPS group. Successful salvage resection was achieved in 17 (25.8%) patients after tumor-downstaging (combination 12 vs. NPS 5, P = 0.03). The median overall survival (OS) was 16.8 months in the combination group and 10.0 months in the NPS group (P = 0.002). Remarkable OS benefit was observed in patients with decline in CA19-9 of ≥ 50% (16.0 vs. 6.5, P = 0.003), reduction in 18F-fluorodeoxyglucose uptake of primary tumor of ≥ 50% (16.5 vs. 10.0, P
- Subjects :
- medicine.medical_specialty
Paclitaxel
medicine.medical_treatment
Deoxycytidine
Gastroenterology
Pancreatic tumor
Albumins
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
Humans
Medicine
Adverse effect
Immune Checkpoint Inhibitors
Retrospective Studies
Chemotherapy
business.industry
Liver Neoplasms
Retrospective cohort study
medicine.disease
Primary tumor
Pancreatic Neoplasms
Regimen
Cardiothoracic surgery
Surgery
business
Carcinoma, Pancreatic Ductal
Abdominal surgery
Subjects
Details
- ISSN :
- 14352451 and 14352443
- Volume :
- 407
- Database :
- OpenAIRE
- Journal :
- Langenbeck's Archives of Surgery
- Accession number :
- edsair.doi.dedup.....84455b487dfcbb5b643209ab07b4ac0b