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Prohormone atrial natriuretic peptides 1–30, 31–67, and 99–126 increase in proportion to right ventricular pacing rate
- Source :
- American Heart Journal. 117:385-390
- Publication Year :
- 1989
- Publisher :
- Elsevier BV, 1989.
-
Abstract
- To determine whether heart rate contributes to release of three new peptide hormones synthesized in the heart, right ventricular pacing at rates of 100, 125, 150, and 180 bpm was performed in six dogs with measurement of the plasma concentration of these peptides at each pacing rate while right atrial and systemic blood pressures were simultaneously monitored. These three peptides of the 126-amino-acid prohormone of atrial natriuretic factor (ANF), consisting of amino acids 1-30 (pro ANF 1-30), 31-67 (pro ANF 31-67), and 99-126 (ANF), increased incrementally at paced heart rates of 125, 150, and 180 bpm (r = 0.8, p less than 0.001). Right atrial pressure decreased with increasing heart rate but systemic blood pressure did not decrease until the heart rate was 180 bpm, at which time these peptides had obtained their maximal circulating concentrations. After pacing, mean right atrial pressure and levels of ANF returned to prepacing values within 30 minutes. Mean arterial blood pressure, on the other hand, increased throughout the 120-minute period after pacing. At 2 hours after pacing, levels of pro ANFs 1-30 and 31-67 were elevated compared with prepacing values. These data demonstrate that, at heart rates of 125 bpm and above, pro ANF 1-30, pro ANF 31-67, and ANF (99-126) are simultaneously and incrementally released in direct proportion to heart rate. The sustained elevation in pro ANFs 1-30 and 31-67 seen 2 hours after pacing suggests that they may contribute to the prolonged diuresis seen after cardiac pacing or tachycardia.
- Subjects :
- Male
Tachycardia
medicine.medical_specialty
Time Factors
Heart Ventricles
Diuresis
Hemodynamics
Peptide hormone
Dogs
Atrial natriuretic peptide
Internal medicine
Heart rate
otorhinolaryngologic diseases
Animals
Medicine
Heart Atria
Protein Precursors
business.industry
Osmolar Concentration
Cardiac Pacing, Artificial
Central venous pressure
Femoral Vein
Peptide Fragments
Endocrinology
Blood pressure
cardiovascular system
Cardiology
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Atrial Natriuretic Factor
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 00028703
- Volume :
- 117
- Database :
- OpenAIRE
- Journal :
- American Heart Journal
- Accession number :
- edsair.doi.dedup.....843bbb29d89828a9ef986c7876517678
- Full Text :
- https://doi.org/10.1016/0002-8703(89)90784-9